Occupational prolonged organic solvent exposure in shoemakers brain MR spectroscopy findings

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dc.contributor.authorAlkan, Alpay
dc.contributor.authorKutlu, Ramazan
dc.contributor.authorTarık, Hallaç
dc.contributor.authorSığırcı, Ahmet
dc.contributor.authorEmul, Murat
dc.contributor.authorPala, Nilgün
dc.contributor.authorAltınok, Tayfun
dc.contributor.authorAslan, Mehmet
dc.contributor.authorSaraç, Kaya
dc.contributor.authorÖzcan, Abdulcemal
dc.date.accessioned2017-05-22T11:06:07Z
dc.date.available2017-05-22T11:06:07Z
dc.date.issued2004
dc.departmentİnönü Üniversitesien_US
dc.description.abstractOur purpose was to investigate, by magnetic resonance (MR) spectroscopy, the metabolite changes in the brains of subjects in the shoemaking industry who had been chronically exposed to organic solvents. A total of 49 male subjects and 30 age-matched healthy volunteers underwent detailed neurological and psychiatric examinations. All subjects had long-echo [repetition time (TR) 2000 ms, echo time (TE) 136 ms] single-voxel MR spectroscopy. Voxels (15 15 15 mm3 ) were placed in the parietal white matter, thalamus, and basal ganglia. N-acetylaspartate (NAA)/creatine (Cr) and choline (Cho)/Cr ratios were calculated. There was no significant difference between the study subjects and the control group in NAA/Cr ratios obtained from thalamus, basal ganglia, and parietal white matter. Cho/Cr ratios in thalamus, basal ganglia, and parietal white matter were found to be significantly increased compared to controls. There was a positive correlation between basal ganglia Cho/Cr ratio and duration of exposure (r 0.63). MR spectroscopy should be performed to reveal metabolite changes and determine the degree of brain involvement in solvent-related industry workers.en_US
dc.identifier.citationAlkan, A. Kutlu, R. Tarık, H. Sığırcı, A. Emul, M. Pala, N. Altınok, T. Aslan, M. Saraç, K. Özcan, A. (2004). Occupational prolonged organic solvent exposure in shoemakers brain MR spectroscopy findings. Magnetic Resonance Imaging, 22(5), 707–713.en_US
dc.identifier.doi10.1016/j.mri.2004.01.070en_US
dc.identifier.endpage713en_US
dc.identifier.issn0730725X
dc.identifier.issue5en_US
dc.identifier.startpage707en_US
dc.identifier.urihttp://linkinghub.elsevier.com/retrieve/pii/S0730725X04001092
dc.identifier.urihttps://hdl.handle.net/11616/6928
dc.identifier.volume22en_US
dc.language.isoenen_US
dc.publisherMagnetic Resonance Imagingen_US
dc.relation.ispartofMagnetic Resonance Imagingen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectOccupational exposureen_US
dc.subjectSolventsen_US
dc.subjectMagnetic resonance spectroscopyen_US
dc.titleOccupational prolonged organic solvent exposure in shoemakers brain MR spectroscopy findingsen_US
dc.typeArticleen_US

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