The role of A268V exon-7 polymorphism of PPARA in development of axial spondyloarthritis

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dc.authoridAKBULUT, EKREM/0000-0002-7526-9835
dc.authorwosidAKBULUT, EKREM/Q-2765-2015
dc.contributor.authorAkbulut, Ekrem
dc.contributor.authorYolbas, Servet
dc.contributor.authorOzgen, Metin
dc.date.accessioned2024-08-04T20:10:10Z
dc.date.available2024-08-04T20:10:10Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjectives: Axial spondyloarthritis (axSpA) is a chronic inflammatory disease that mainly affects the axial skeleton. Peroxisome proliferator activated receptor alpha (PPARA) is an intracellular transcription factor, which play a role in inflammation and osteoblasting activity. This study is designed to investigate the relationship of NG_012204.2:p.A1a268Val polymorphism of PPARA with axSpA risk and its role in disease development. Methods: This study was conducted with 168 patients and 181 controls. Genotyping was done with MALDITOF. Gene expression level was analyzed by quantitative real time PCR (RT-qPCR). The protein homology models of PPARA were created with ProMod3. Ligand binding dynamics were tested using the AutoDock4 docking program. Statistical evaluations were made with SPSS (ver24) and GeneGlobe. Results: Our results showed that C>T polymorphism causing NG_012204.2:p.A1a268Val change was associated with disease risk (p=0.024) and T allele increased disease risk 1.7 times (95% CI=1.070-2.594). PPARA expression decreased (p<0.05) in individuals carrying the T allele. We determined that the ligand entry pocket was opened 1.1 A in the polymorphic PPARA. Polymorphic change caused a decrease in the ligand binding affinity. Conclusions: Our results provide an important contribution to elucidating the development of axSpA and demonstrate the potential of PPARA as a marker for the diagnosis of axSpA.en_US
dc.description.sponsorshipMunzur University Health Faculty Research Budget; Munzur University Scientific Research Department [MFMUB017-09]en_US
dc.description.sponsorshipThis study was supported by Munzur University Health Faculty Research Budget and Munzur University Scientific Research Department (Grant number: MFMUB017-09).en_US
dc.identifier.doi10.1515/tjb-2021-0086
dc.identifier.endpage111en_US
dc.identifier.issn0250-4685
dc.identifier.issn1303-829X
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85126303080en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage103en_US
dc.identifier.trdizinid1171790en_US
dc.identifier.urihttps://doi.org/10.1515/tjb-2021-0086
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1171790
dc.identifier.urihttps://hdl.handle.net/11616/92633
dc.identifier.volume47en_US
dc.identifier.wosWOS:000740003400001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherWalter De Gruyter Gmbhen_US
dc.relation.ispartofTurkish Journal of Biochemistry-Turk Biyokimya Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectaxial spondyloarthritisen_US
dc.subjectdisease risken_US
dc.subjectinflammationen_US
dc.subjectperoxisome proliferator activated receptor alphaen_US
dc.subjectpolymorphismen_US
dc.titleThe role of A268V exon-7 polymorphism of PPARA in development of axial spondyloarthritisen_US
dc.typeArticleen_US

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