Impact of ghrelin on vitreous cytokine levels in an experimental uveitis model

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dc.authoridGül, Fatih Cem/0000-0002-6531-4006
dc.authoridGül, Fatih Cem/0000-0002-6531-4006
dc.authoridIlhan, Nevin/0000-0002-0208-8929
dc.authoridTurgut, Burak/0000-0002-5393-0557
dc.authorwosidGül, Fatih Cem/AHA-8409-2022
dc.authorwosidGül, Fatih Cem/G-8663-2015
dc.authorwosidIlhan, Nevin/J-5761-2017
dc.authorwosidTurgut, Burak/K-8932-2014
dc.contributor.authorTurgut, Burak
dc.contributor.authorGul, Fatih Cem
dc.contributor.authorDagli, Ferda
dc.contributor.authorIlhan, Nevin
dc.contributor.authorOzgen, Metin
dc.date.accessioned2024-08-04T20:37:23Z
dc.date.available2024-08-04T20:37:23Z
dc.date.issued2013
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: The purpose of this study was to investigate the effect of intraperitoneal ghrelin on vitreous levels of interleukin (IL)-1, IL-6, and tumor necrosis factor-alpha (TNF-alpha) and to compare its effects with those of intraperitoneal infliximab in an experimental uveitis model. Methods: Twenty-four male rats were assigned to four groups of six rats in each. All the rats, except for those in group 1 (controls), were injected intravitreally with concanavalin A to induce experimental uveitis. Rats in group 2 (sham) were not given any treatment after uveitis was induced. Rats in group 3 were given intraperitoneal infliximab 0.5 mg/100 mL on days 0, 1, 3, 5, and 7 following induction of uveitis on day 14 of the study. Rats in group 4 were given intraperitoneal ghrelin 10 ng/kg/day for 7 days following induction of uveitis. On day 21 of the study, enucleated globes were subjected to histopathologic examination. Vitreous levels of IL-1, IL-6, and TNF-alpha were measured by enzyme-linked immunosorbent assay. Results: Vitreous levels of IL-1, IL-6, and TNF-alpha were significantly increased in the sham group relative to the control group (P < 0.05), but showed a significant decrease in the group treated with infliximab (P < 0.05). Cytokine levels also decreased in the ghrelin-treated group, but the decrease was not statistically significant (P > 0.05). Conclusion: Ghrelin failed to decrease the IL-1, IL-6, and TNF-alpha levels that play a critical role in the pathogenesis of uveitis.en_US
dc.identifier.doi10.2147/DDDT.S39453
dc.identifier.endpage24en_US
dc.identifier.issn1177-8881
dc.identifier.pmid23341733en_US
dc.identifier.scopus2-s2.0-84872335398en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage19en_US
dc.identifier.urihttps://doi.org/10.2147/DDDT.S39453
dc.identifier.urihttps://hdl.handle.net/11616/95923
dc.identifier.volume7en_US
dc.identifier.wosWOS:000313560300001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherDove Medical Press Ltden_US
dc.relation.ispartofDrug Design Development and Therapyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectuveitisen_US
dc.subjecttumor necrosis factor-alphaen_US
dc.subjectinterleukin-1en_US
dc.subjectinterleukin-6en_US
dc.subjectinfliximaben_US
dc.subjectghrelinen_US
dc.titleImpact of ghrelin on vitreous cytokine levels in an experimental uveitis modelen_US
dc.typeArticleen_US

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