Immunohistochemical evaluation of the effects of nebivolol on intimal hyperplasia following endothelial injury

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dc.authoridÖZERCAN, ibrahim Hanifi/0000-0002-8781-8838
dc.authoridUstundag, Bilal/0000-0001-6621-2450
dc.authoriduysal, ayhan/0000-0001-7526-5554
dc.authorwosidÜSTÜNDAĞ, BİLAL/V-9780-2018
dc.authorwosidColak, M. Cengiz/ABI-3394-2020
dc.authorwosidÖZERCAN, ibrahim Hanifi/W-7883-2018
dc.authorwosidUysal, Ayhan/W-5118-2018
dc.contributor.authorAkar, Ilker
dc.contributor.authorRahman, Ali
dc.contributor.authorColak, M. Cengiz
dc.contributor.authorUstundag, Bilal
dc.contributor.authorOzercan, Ibrahim Hanifi
dc.contributor.authorUysal, Ayhan
dc.date.accessioned2024-08-04T21:02:25Z
dc.date.available2024-08-04T21:02:25Z
dc.date.issued2011
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAim: Intimal hyperplasia is a vascular remodeling process. It is a clinical problem that forms in the vascular wall as a result of smooth muscle cell migration, proliferation, and extracellular matrix accumulation. In this study we examined the immunohistochemical evaluation of the effects of nebivolol on intimal hyperplasia in damaged endothelial tissue. Materials and methods: The study was conducted using 21 rabbits equally divided into 3 groups: control, solvent, and nebivolol. The rabbits in the control group only underwent balloon injury of the abdominal aorta. The rabbits in the solvent group and nebivolol group underwent balloon injury and were treated with solvent and nebivolol intraperitoneally during the study. At the end of the study, the abdominal aortas were harvested. The intimal and medial areas were measured and the intima/media ratios were calculated. Tissue nitric oxide levels were determined and immunohistochemical findings were evaluated. Results: Statistically there were no differences between the control and solvent groups with respect to the intimal and medial areas, intima/media ratios, or the tissue nitric oxide (NO) levels. The neointimal thickening was significantly less in the nebivolol group than in the control and solvent groups (P < 0.001). Intima/media ratio was decreased in the nebivolol group (P < 0.001). Tissue nitric oxide levels were greater in the nebivolol group than in the control and solvent groups (P < 0.01). Immunohistochemical data in the nebivolol group were significantly lower as compared with the other groups (P < 0.05). Conclusion: Nebivolol may be a useful agent in early restenosis after vascular reconstructive procedures.en_US
dc.identifier.doi10.3906/sag-0809-41
dc.identifier.endpage63en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-83255192494en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage53en_US
dc.identifier.trdizinid111821en_US
dc.identifier.urihttps://doi.org/10.3906/sag-0809-41
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/111821
dc.identifier.urihttps://hdl.handle.net/11616/104746
dc.identifier.volume41en_US
dc.identifier.wosWOS:000288413100008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technological Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIntimal hyperplasiaen_US
dc.subjectnitric oxideen_US
dc.subjectnebivololen_US
dc.titleImmunohistochemical evaluation of the effects of nebivolol on intimal hyperplasia following endothelial injuryen_US
dc.typeArticleen_US

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