DETERMINATION OF POTENTIAL DRUG-DRUG INTERACTIONS IN GENERAL PEDIATRIC WARD PATIENTS: A CROSS-SECTIONAL STUDY

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dc.authorscopusid57221765512
dc.authorscopusid58628055900
dc.authorscopusid57219039015
dc.authorscopusid57289798700
dc.contributor.authorMemis H.
dc.contributor.authorÇakir A.
dc.contributor.authorOzdemir N.
dc.contributor.authorGün Z.Ü.
dc.date.accessioned2024-08-04T20:03:45Z
dc.date.available2024-08-04T20:03:45Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: This study seeks to identify potential drug-drug interactions (pDDIs) in hospitalized patients and compare two commercial drug interaction databases. Material and Method: This prospective cross-sectional study was conducted between February and May 2022 in a tertiary care hospital's general pediatric ward. UpToDate® and Micromedex® Drug Interaction databases were used to determine pDDIs. Result and Discussion: In total, 267 pDDIs were found in 51 pediatric patients' medication lists (181 via UpToDate® and 86 via Micromedex®). The use of at least five different systemic drugs concurrently was statistically significant between groups of patients who experienced at least one pDDI and those who did not. The binary logistic regression analysis showed that a one-drug increase in the total number of drugs a patient received during hospitalization increased the probability of pDDIs by 2.12-fold (CI: 1.321-3.417, p=0.002). The concordance rate between UpToDate® and Micromedex® databases for pDDI determination was 84.31% (kappa coefficient=0.676, standard error=0.102, (p ? 0.001)). When the UpToDate® database was assumed as a reference database, the Micromedex® database's sensitivity, specificity, positive predictive value, negative predictive value, and accuracy in determining pDDIs were 79.41%, 94.12%, 96.43%, 69.56%, and 84.5%. To avoid missing pDDIs, utilizing multiple drug interaction databases may be of benefit. © 2023 University of Ankara. All rights reserved.en_US
dc.description.sponsorshipWe like to convey our deepest appreciation to the healthcare team of the general pediatric ward for their assistance throughout the study's conduction.en_US
dc.identifier.doi10.33483/jfpau.1241376
dc.identifier.endpage530en_US
dc.identifier.issn2564-6524
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85172908866en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage520en_US
dc.identifier.trdizinid1175546en_US
dc.identifier.urihttps://doi.org/10.33483/jfpau.1241376
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1175546
dc.identifier.urihttps://hdl.handle.net/11616/92045
dc.identifier.volume47en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherUniversity of Ankaraen_US
dc.relation.ispartofAnkara Universitesi Eczacilik Fakultesi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectChildrenen_US
dc.subjectclinical pharmacisten_US
dc.subjectdrug interactionsen_US
dc.subjectpediatric patientsen_US
dc.titleDETERMINATION OF POTENTIAL DRUG-DRUG INTERACTIONS IN GENERAL PEDIATRIC WARD PATIENTS: A CROSS-SECTIONAL STUDYen_US
dc.title.alternativeGENEL PEDİYATRI SERVİSİ HASTALARINDA POTANSİYEL İLAÇ-İLAÇ ETKİLEŞİMLERİNİN SAPTANMASI: BİR KESİTSEL ÇALIŞMAen_US
dc.typeArticleen_US

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