Effects of Different Positive End-Expiratory Pressure Values on Liver Function and Indocyanine Green Clearance Test in Liver Transplantation Donors: A Prospective, Randomized, Double-Blind Study

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dc.authoridIsik, Burak/0000-0002-2395-3985
dc.authoridToprak, Hüseyin İlksen/0000-0001-9293-8116
dc.authoridYologlu, Saim/0000-0002-9619-3462
dc.authoridaydogan, mustafa said/0000-0002-7106-1156
dc.authorwosidIsik, Burak/A-6657-2018
dc.authorwosidToprak, Hüseyin İlksen/AAN-4023-2020
dc.authorwosidYologlu, Saim/ABI-8014-2020
dc.authorwosidbıçakcıoğlu, murat/ABB-5579-2020
dc.authorwosidaydogan, mustafa said/AAA-2828-2021
dc.contributor.authorBicakcioglu, M.
dc.contributor.authorAydogan, M. S.
dc.contributor.authorSayan, H.
dc.contributor.authorToprak, H. I.
dc.contributor.authorIsik, B.
dc.contributor.authorYilmaz, S.
dc.contributor.authorYologlu, S.
dc.date.accessioned2024-08-04T20:40:17Z
dc.date.available2024-08-04T20:40:17Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.description13th Luso-Brazilian Transplantation Congress / 12th Portuguese Transplantation Congress / 1st Iberian Meeting of Transplantation -- OCT 09-11, 2014 -- Lisbon, PORTUGALen_US
dc.description.abstractIntroduction. The aim of this study was demonstrate the influence of different positive end-expiratory pressure (PEEP) values on blood flow of the liver by indocyanine green (ICG) clearance test in donor patients. Methods. ICG clearance tests were conducted concurrently using a noninvasive monitor that tracks the plasma disappearance rate of ICG (PDR-ICG%/min) and 15-minute retention rate after administration of ICG (ICG-R15%). This study was performed in 40 patients who underwent right hepatectomy. Results. The positive end-expiratory pressure (PEEP) was 0 cm H2O in the first (control) group (group K) and 10 mm Hg in the second study group (group P). ICG clearance test values before general anesthesia (T0), after induction of general anesthesia (T1), after transection (T2), 24 hours postoperative (T3), and 72 hours postoperative (T4) were recorded. Simultaneously, hemoglobin (Hgb), hematocrit (Hct), platelet count, plasma levels of prothrombin (PT), International Normalized Ratio (INR), total bilirubin, direct bilirubin, albumin, aspartate aminotransferase, and alanine aminotransferase values were analyzed. In terms of the plasma disappearance rate and retention rate of ICG 15 minutes after administration, significant difference was not observed between groups. PT and INR values were different within comparisons groups (P < .05). There were significant differences in Hgb and Hct values compared with the baseline values (T0) within group (T1, T2, T3, T4) measurements and between group comparisons at T0 and T4 (P < .05). Systemic arterial pressure, mean arterial pressure, and central venous pressure were significantly different between the groups (P <.05). Conclusions. Given the small magnitude and limited clinical significance of these changes, we conclude that PEEP values between 0 and 10 cm H2O have no effect on global liver function and liver-related liabilities tests in patients undergoing elective liver donor surgery.en_US
dc.identifier.doi10.1016/j.transproceed.2015.01.028
dc.identifier.endpage1193en_US
dc.identifier.issn0041-1345
dc.identifier.issn1873-2623
dc.identifier.issue4en_US
dc.identifier.pmid26036551en_US
dc.identifier.scopus2-s2.0-84930402942en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1190en_US
dc.identifier.urihttps://doi.org/10.1016/j.transproceed.2015.01.028
dc.identifier.urihttps://hdl.handle.net/11616/96808
dc.identifier.volume47en_US
dc.identifier.wosWOS:000356184000077en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofTransplantation Proceedingsen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPeepen_US
dc.subjectHemodynamicsen_US
dc.titleEffects of Different Positive End-Expiratory Pressure Values on Liver Function and Indocyanine Green Clearance Test in Liver Transplantation Donors: A Prospective, Randomized, Double-Blind Studyen_US
dc.typeConference Objecten_US

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