Acute liver failure in Turkey: A systematic review

dc.authoridErsan, Veysel/0000-0002-1510-0288
dc.authoridKayaalp, Cuneyt/0000-0003-4657-2998
dc.authorwosidKayaalp, Cuneyt/AAH-1764-2021
dc.authorwosidErsan, Veysel/AAB-9595-2020
dc.contributor.authorKayaalp, Cuneyt
dc.contributor.authorErsan, Veysel
dc.contributor.authorYilmaz, Sezai
dc.date.accessioned2024-08-04T20:09:46Z
dc.date.available2024-08-04T20:09:46Z
dc.date.issued2014
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground/Aims: To present the causes of acute liver failure in Turkey. Materials and Methods: International and national medical research databanks were searched for publications related to acute liver failure and originating from Turkey. Patients in the databank of acute liver failure of our center were also added to this literature search. Patients were evaluated for age, gender, etiology, treatment modality, and outcomes. Results: A total of 308 patients were analyzed. Hepatitis A (20.9%) for children and hepatitis B (34.7%) for adults were the most common causes of acute liver failure. Cryptogenic (18%) and metabolic (14%) reasons were the followings. Wilson's disease was the most common cause of metabolic diseases. Mushroom intoxication was the most frequent factor of toxic liver failure for both adults and children (13%). Firework intoxication, including yellow phosphorus, is an indigenous factor. Anti-tuberculosis agents (3.2%) were the main cause of drug-induced acute liver failures (9%). Paracetamol was responsible for only 0.7% of all acute liver failures. Survival of the transplanted patients (n=118) was better than the non-transplanted patients (n=178) (65% vs. 36% respectively, p<0.001) Conclusion: Preventable causes of acute liver failure in Turkey include hepatitis viruses and intoxication. Active vaccination and public awareness can decrease the number of acute liver failures. Paracetamol is not an emerging reason for acute liver failure in Turkey now, but selling it over the counter may increase the risks.en_US
dc.identifier.doi10.5152/tjg.2014.4231
dc.identifier.endpage40en_US
dc.identifier.issn1300-4948
dc.identifier.issn2148-5607
dc.identifier.issue1en_US
dc.identifier.pmid24918128en_US
dc.identifier.scopus2-s2.0-84902588293en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage35en_US
dc.identifier.trdizinid221231en_US
dc.identifier.urihttps://doi.org/10.5152/tjg.2014.4231
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/221231
dc.identifier.urihttps://hdl.handle.net/11616/92421
dc.identifier.volume25en_US
dc.identifier.wosWOS:000338051700006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAvesen_US
dc.relation.ispartofTurkish Journal of Gastroenterologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcute liver failureen_US
dc.subjecthepatitis virusesen_US
dc.subjecttransplantationen_US
dc.subjectsystematic reviewen_US
dc.subjectepidemiologyen_US
dc.titleAcute liver failure in Turkey: A systematic reviewen_US
dc.typeReview Articleen_US

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