Acute Lymphoblastic Leukemia in Routine Practice: A Turkish Multicenter Study

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dc.authoridSevindik, Omur Gokmen/0000-0001-9636-4113
dc.authoridkarakuş, volkan/0000-0001-9178-2850
dc.authoridDogu, Mehmet Hilmi/0000-0001-7237-2637
dc.authoridKaynar, Leylagul/0000-0002-2035-9462
dc.authoridDemirkan, Fatih/0000-0002-1172-8668
dc.authoridCiftciler, Rafiye/0000-0001-5687-8531
dc.authoridErkurt, Mehmet Ali/0000-0002-3285-417X
dc.authorwosidBuyukasik, Yahya/AAJ-3228-2020
dc.authorwosidSevindik, Omur Gokmen/AAD-5452-2021
dc.authorwosidkarakuş, volkan/A-4238-2018
dc.authorwosidDogu, Mehmet Hilmi/W-2255-2017
dc.authorwosidKaynar, Leylagul/F-6991-2013
dc.authorwosidDemirkan, Fatih/AAD-6403-2019
dc.authorwosidCiftciler, Rafiye/AAC-1734-2020
dc.contributor.authorCiftciler, Rafiye
dc.contributor.authorSevindik, Omur Gokmen
dc.contributor.authorTekgunduz, Ali Irfan Emre
dc.contributor.authorErkurt, Mehmet Ali
dc.contributor.authorVural, Filiz
dc.contributor.authorTurgut, Burhan
dc.contributor.authorKaynar, Leylagul
dc.date.accessioned2024-08-04T20:09:59Z
dc.date.available2024-08-04T20:09:59Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: Significant developments occurred in the clinical management of acute lymphoblastic leukemia (ALL) in adults in recent decades. However, treatment results are still not satisfactory, especially in routine practice. The objective of this study was to evaluate the general clinical features, treatment details, and outcomes of a large group of patients followed in multiple centers in Turkey with a diagnosis of ALL. Materials and Methods: A retrospective analysis of the data of patients with ALL was made, the patients having been diagnosed and treated between January 2003 and June 2017 by different protocols in the hematology clinics of ten different centers. A total of 288 patients, aged between 17 and 76 years old, were included in the study. In this retrospective multicenter analysis of patients with ALL, classification of patients was performed based on treatment period, Philadelphia chromosome positivity, treatment regimen, and administration of allogeneic hematopoietic stem cell transplantation (allo-HSCT). Results: The majority of cases were B-cell in origin, while 224 patients had B-ALL and 64 of the patients had T-ALL. Median follow-up duration for all patients was 18.2 months (range: 0.03-161 months). Philadelphia chromosome positivity was determined in 49 patients (21.9%), and 54 patients (18.8%) were receiving allo-HSCT. After induction chemotherapy, 219 patients (76.0%) achieved complete remission, 32 patients (11.2%) were evaluated as treatment refractory, and 37 patients (12.8%) were deceased. Median overall survival was 47.7 months (95% confidence interval: 36.1-59.2) and median disease-free survival was 23.4 months (95% confidence interval: 6.7-40.0) for all patients. Conclusion: Multicenter studies are extremely important for defining the specific clinical features of a particular disease. The results of this study will make a significant contribution to the literature as they reflect real-life data providing valuable information about the Turkish ALL patient profile.en_US
dc.identifier.doi10.4274/tjh.galenos.2019.2019.0008
dc.identifier.endpage177en_US
dc.identifier.issn1300-7777
dc.identifier.issn1308-5263
dc.identifier.issue3en_US
dc.identifier.pmid31131598en_US
dc.identifier.scopus2-s2.0-85070409005en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage169en_US
dc.identifier.trdizinid353715en_US
dc.identifier.urihttps://doi.org/10.4274/tjh.galenos.2019.2019.0008
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/353715
dc.identifier.urihttps://hdl.handle.net/11616/92541
dc.identifier.volume36en_US
dc.identifier.wosWOS:000482629200004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherGalenos Yayinciliken_US
dc.relation.ispartofTurkish Journal of Hematologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcute lymphoblastic leukemiaen_US
dc.subjectPediatric regimenen_US
dc.subjectPediatric-inspired regimenen_US
dc.subjectPhiladelphia chromosomeen_US
dc.titleAcute Lymphoblastic Leukemia in Routine Practice: A Turkish Multicenter Studyen_US
dc.typeArticleen_US

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