Electrospun PEO-based composite coatings containing three varieties of nano-hydroxyapatite for titanium implants: A multifunctional approach to enhancing osteointegration and antibacterial activity
Küçük Resim Yok
Tarih
2026
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Effective osseointegration and infection prevention remain critical challenges for metallic implants. In this study, we developed a facile and dual-functional coating strategy by electrospun poly(ethylene oxide) (PEO) fibers incorporated with nano-hydroxyapatite (HA) particles onto pretreated titanium (Ti) surfaces. The HA particles were synthesized via biomimetic precipitation from concentrated simulated body fluid (10 x SBF) under three different conditions: (i) at room temperature (R-HA), (ii) using microwave energy (M-HA), and (iii) in the presence of boric acid (B-HA). Crosslinking with pentaerythritol triacrylate (PETA) under UV irradiation ensured stable fiber coatings. In vitro analyses using MC3T3-E1 pre-osteoblasts and Staphylococcus epidermidis (both biofilm-forming and non-forming strains) strains revealed that while pristine PEO reduced cell attachment, HA incorporation restored proliferation and enhanced osteogenic differentiation, with B-HA showing the highest osteogenic marker expression. Meanwhile, R-HA/PEO coatings exhibited the strongest anti-adhesive effect against bacterial colonization. These results demonstrate that the combination of electrospun PEO fibers with HA-particularly boron-substituted HA-provides a synergistic approach to simultaneously promote bone integration and inhibit bacterial adhesion. This work lays the groundwork for developing smart, long-term implant coatings and highlights the potential for future in vivo studies to validate extended clinical efficacy.
Açıklama
Anahtar Kelimeler
Electrospinning, Poly (ethylene oxide), Titanium, Surface coating, Implant material, Hydroxyapatite, Simulated body fluid, Boron
Kaynak
Colloids and Surfaces A-Physicochemical and Engineering Aspects
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
732
