Electrospun PEO-based composite coatings containing three varieties of nano-hydroxyapatite for titanium implants: A multifunctional approach to enhancing osteointegration and antibacterial activity

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dc.contributor.authorGumusderelioglu, Menemse
dc.contributor.authorSimsek, Murat
dc.contributor.authorKalelioglu, Derya
dc.contributor.authorCakmak, Anil Sera
dc.contributor.authorCoskun, Sema
dc.contributor.authorSana, Farzin
dc.date.accessioned2026-04-04T13:35:10Z
dc.date.available2026-04-04T13:35:10Z
dc.date.issued2026
dc.departmentİnönü Üniversitesi
dc.description.abstractEffective osseointegration and infection prevention remain critical challenges for metallic implants. In this study, we developed a facile and dual-functional coating strategy by electrospun poly(ethylene oxide) (PEO) fibers incorporated with nano-hydroxyapatite (HA) particles onto pretreated titanium (Ti) surfaces. The HA particles were synthesized via biomimetic precipitation from concentrated simulated body fluid (10 x SBF) under three different conditions: (i) at room temperature (R-HA), (ii) using microwave energy (M-HA), and (iii) in the presence of boric acid (B-HA). Crosslinking with pentaerythritol triacrylate (PETA) under UV irradiation ensured stable fiber coatings. In vitro analyses using MC3T3-E1 pre-osteoblasts and Staphylococcus epidermidis (both biofilm-forming and non-forming strains) strains revealed that while pristine PEO reduced cell attachment, HA incorporation restored proliferation and enhanced osteogenic differentiation, with B-HA showing the highest osteogenic marker expression. Meanwhile, R-HA/PEO coatings exhibited the strongest anti-adhesive effect against bacterial colonization. These results demonstrate that the combination of electrospun PEO fibers with HA-particularly boron-substituted HA-provides a synergistic approach to simultaneously promote bone integration and inhibit bacterial adhesion. This work lays the groundwork for developing smart, long-term implant coatings and highlights the potential for future in vivo studies to validate extended clinical efficacy.
dc.identifier.doi10.1016/j.colsurfa.2025.139164
dc.identifier.issn0927-7757
dc.identifier.issn1873-4359
dc.identifier.orcid0000-0001-7113-0484
dc.identifier.orcid0000-0002-6301-5184
dc.identifier.scopus2-s2.0-105023959448
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.colsurfa.2025.139164
dc.identifier.urihttps://hdl.handle.net/11616/109670
dc.identifier.volume732
dc.identifier.wosWOS:001638651600006
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofColloids and Surfaces A-Physicochemical and Engineering Aspects
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250329
dc.subjectElectrospinning
dc.subjectPoly (ethylene oxide)
dc.subjectTitanium
dc.subjectSurface coating
dc.subjectImplant material
dc.subjectHydroxyapatite
dc.subjectSimulated body fluid
dc.subjectBoron
dc.titleElectrospun PEO-based composite coatings containing three varieties of nano-hydroxyapatite for titanium implants: A multifunctional approach to enhancing osteointegration and antibacterial activity
dc.typeArticle

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