Value of Glut-1 and Koc Markers in the Differential Diagnosis of Reactive Mesothelial Hyperplasia, Malignant Mesothelioma and Pulmonary Adenocarcinoma

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dc.authoridKılıçarslan, Ahmet/0000-0001-8193-8778
dc.authoridDagli, Adile Ferda/0000-0003-4077-4134
dc.authorwosidKılıçarslan, Ahmet/HSH-9915-2023
dc.authorwosidartaş, gökhan/HTR-8629-2023
dc.authorwosidDagli, Adile Ferda/W-7878-2018
dc.contributor.authorUcer, Ozlem
dc.contributor.authorDagli, Adile Ferda
dc.contributor.authorKilicarslan, Ahmet
dc.contributor.authorArtas, Gokhan
dc.date.accessioned2024-08-04T21:02:26Z
dc.date.available2024-08-04T21:02:26Z
dc.date.issued2013
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: Malignant mesothelioma (MM) is a primary malignant tumor developing from mesothelial cells lining the serosal surfaces and particularly the pleura, and has a very poor prognosis. It may display a variety of histological patterns and has a wide spectrum of cytomorphological characteristics, causing problems in its differential diagnosis from lung adenocarcinomas and sometimes from benign mesothelial proliferations. Immunohistochemical examination is the most useful method for this distinction. In our study, we aimed to determine the value of glucose transporter isoform-1 (GLUT-1) and K homology domain-containing protein (KOC) markers in the differential diagnosis of reactive mesothelial hyperplasia, malignant mesothelioma and lung adenocarcinoma. Material and Method: Our study included 30 samples of malignant mesothelioma, 30 samples of pulmonary adenocarcinoma and 30 samples of reactive mesothelial hyperplasia selected from the archives of the Firat University Hospital's Pathology Department Laboratory. The samples were applied GLUT-1 and KOC markers by immunohistochemistry and the place of these markers in the differential diagnosis was examined. Results: GLUT-1 was found positive in 80% of malignant mesothelioma cases, 83.3% of adenocarcinoma cases and 6.6% of reactive mesothelial hyperplasia cases. KOC was positive in 83.3% of malignant mesothelioma cases, 76.6% of adenocarcinoma cases and 46.6% of reactive mesothelial hyperplasia cases. There was no statistically significant difference between malignant mesothelioma and lung adenocarcinoma cases in terms of the diffuseness and intensity of staining with GLUT-1, whereas a significant difference was established when these groups were compared with reactive mesothelial hyperplasia cases. However, the KOC staining diffuseness and intensity results were similar to those obtained with GLUT-1. Conclusion: In conclusion, GLUT-1 and KOC markers do not differentiate malignant mesotheliomas from pulmonary adenocarcinomas but can be useful in differentiating reactive mesothelial hyperplasia from malignant mesothelioma and lung adenocarcinoma.en_US
dc.identifier.doi10.5146/tjpath.2013.01158
dc.identifier.endpage100en_US
dc.identifier.issn1018-5615
dc.identifier.issn1309-5730
dc.identifier.issue2en_US
dc.identifier.pmid23661345en_US
dc.identifier.scopus2-s2.0-84877279997en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage94en_US
dc.identifier.trdizinid159559en_US
dc.identifier.urihttps://doi.org/10.5146/tjpath.2013.01158
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/159559
dc.identifier.urihttps://hdl.handle.net/11616/104755
dc.identifier.volume29en_US
dc.identifier.wosWOS:000217455300004en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherDe Gruyter Open Ltden_US
dc.relation.ispartofTurkish Journal of Pathologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMesotheliomaen_US
dc.subjectAdenocarcinomaen_US
dc.subjectMesotheliumen_US
dc.subjectGlucose Transporter Type 1en_US
dc.subjectIMP3 proteinen_US
dc.titleValue of Glut-1 and Koc Markers in the Differential Diagnosis of Reactive Mesothelial Hyperplasia, Malignant Mesothelioma and Pulmonary Adenocarcinomaen_US
dc.typeArticleen_US

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