Is Cetrimide-Chlorhexidine Risky for Secondary Sclerosing Cholangitis?
Küçük Resim Yok
Tarih
2014
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wroclaw Medical Univ
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Background. The liver is the most frequent organ for placement of hydatid cyst disease. All known protoscolicidals that are used for echinococcus degeneration have a risk of caustic secondary sclerosing cholangitis. The cetrimide-chlorhexidine combination is an effective protoscolicidal agent for treatment of hydatid liver cysts. Objectives. The aim of this experimental study was to examine this combination for potential risks of caustic secondary sclerosing cholangitis. Material and Methods. Thirty rats were enrolled and divided into two groups. In the study group, 0.15 mL of a cetrimide (0.5%) and chlorhexidine (0.05%) combination was injected into the bile ducts for five minutes. The control group included the same amount of normal saline and waiting period. The rats were followed for 120 days and the living rats were examined for biliary injury by biochemical analysis and histopathology. Results. No specific histopathological findings for caustic sclerosing cholangitis such as bile duct stricture or periductal fibrosis were present in any groups. Other pathological criteria demonstrating inflammation including portal inflammation, bile duct proliferation and necrosis were similar in both groups. Biochemical analysis including a liver function test (aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, gamma-glutamyltranspeptidase) appeared similar to the control group. Conclusions. A cetrimide 0.5% and chlorhexidine 0.05% combination has similar liver function results and histopathological effects to normal saline on bile ducts and it appears to be safe for bile ducts.
Açıklama
Anahtar Kelimeler
cetrimide, chlorhexidine, bile duct, cholangitis, echinococcus granulosus
Kaynak
Advances in Clinical and Experimental Medicine
WoS Q Değeri
Q4
Scopus Q Değeri
Q1
Cilt
23
Sayı
3
