Is Cetrimide-Chlorhexidine Risky for Secondary Sclerosing Cholangitis?

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dc.authoridNessar, Gurel/0000-0002-3891-7565
dc.authoridNessar, Gurel/0000-0002-3891-7565
dc.authoridKayaalp, Cuneyt/0000-0003-4657-2998
dc.authorwosidNessar, Gurel/HPF-6502-2023
dc.authorwosidBALKAN, SALİH MUJDAT/ABI-5250-2020
dc.authorwosidNESSAR, GUREL/AAC-3532-2020
dc.authorwosidKayaalp, Cuneyt/AAH-1764-2021
dc.authorwosidNessar, Gurel/AAM-1430-2020
dc.contributor.authorAydin, Cemalettin
dc.contributor.authorKayaalp, Cuneyt
dc.contributor.authorNessar, Gurel
dc.contributor.authorZengin, Neslihan
dc.contributor.authorBalkan, Mujdat
dc.contributor.authorUnal, Bulent
dc.contributor.authorOzgurtas, Taner
dc.date.accessioned2024-08-04T20:39:49Z
dc.date.available2024-08-04T20:39:49Z
dc.date.issued2014
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground. The liver is the most frequent organ for placement of hydatid cyst disease. All known protoscolicidals that are used for echinococcus degeneration have a risk of caustic secondary sclerosing cholangitis. The cetrimide-chlorhexidine combination is an effective protoscolicidal agent for treatment of hydatid liver cysts. Objectives. The aim of this experimental study was to examine this combination for potential risks of caustic secondary sclerosing cholangitis. Material and Methods. Thirty rats were enrolled and divided into two groups. In the study group, 0.15 mL of a cetrimide (0.5%) and chlorhexidine (0.05%) combination was injected into the bile ducts for five minutes. The control group included the same amount of normal saline and waiting period. The rats were followed for 120 days and the living rats were examined for biliary injury by biochemical analysis and histopathology. Results. No specific histopathological findings for caustic sclerosing cholangitis such as bile duct stricture or periductal fibrosis were present in any groups. Other pathological criteria demonstrating inflammation including portal inflammation, bile duct proliferation and necrosis were similar in both groups. Biochemical analysis including a liver function test (aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, gamma-glutamyltranspeptidase) appeared similar to the control group. Conclusions. A cetrimide 0.5% and chlorhexidine 0.05% combination has similar liver function results and histopathological effects to normal saline on bile ducts and it appears to be safe for bile ducts.en_US
dc.identifier.doi10.17219/acem/37131
dc.identifier.endpage398en_US
dc.identifier.issn1899-5276
dc.identifier.issn2451-2680
dc.identifier.issue3en_US
dc.identifier.pmid24979510en_US
dc.identifier.scopus2-s2.0-84905706355en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage395en_US
dc.identifier.urihttps://doi.org/10.17219/acem/37131
dc.identifier.urihttps://hdl.handle.net/11616/96533
dc.identifier.volume23en_US
dc.identifier.wosWOS:000342277100009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWroclaw Medical Univen_US
dc.relation.ispartofAdvances in Clinical and Experimental Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectcetrimideen_US
dc.subjectchlorhexidineen_US
dc.subjectbile ducten_US
dc.subjectcholangitisen_US
dc.subjectechinococcus granulosusen_US
dc.titleIs Cetrimide-Chlorhexidine Risky for Secondary Sclerosing Cholangitis?en_US
dc.typeArticleen_US

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