Anti-lipoxygenase Evaluation of Different Achillea sp. Extracts
Küçük Resim Yok
Tarih
2025
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wiley-V C H Verlag Gmbh
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
In this present work, in vitro lipoxygenase (LOX) inhibitory activities of methanol extracts and different fractions of six Achillea species [A. biebersteinii, A. millefolium, A. cappadocica, A. wilhelmsii, A. setacea, and A. nobilis subsp. neilreichii] were evaluated. A microplate-based spectrophotometric method was utilized for the LOX assay. The phenolic composition was analyzed using the liquid chromatography-high resolution mass spectrometer (LC-HRMS). As a result, the A. biebersteinii (Malatya locality) ethyl acetate fraction showed the highest lipoxygenase inhibitory activity (72.9% inhibition), followed by the A. cappadocica ethyl acetate fractions with 66.9% and 60.4% inhibition, respectively. The phytochemical LC-HRMS analyses revealed that the active constituents of the studied fractions were vanillic acid, hyperoside, p-coumaric acid, quercetin, and chrysoeriol. The findings showed the active bioassay-directed fractions, as well compounds to the best of our knowledge for the first time, suggesting further future biological, pharmacological, and toxicological evaluations both in vitro and in vivo.
Açıklama
Anahtar Kelimeler
Achillea, anti-inflammatory activity, hyperoside, lipoxygenase, vanillic acid
Kaynak
Chemistry & Biodiversity
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
22
Sayı
10
