Anti-lipoxygenase Evaluation of Different Achillea sp. Extracts

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dc.contributor.authorSubasi, Bilgen
dc.contributor.authorGunbatan, Tugba
dc.contributor.authorGurbuez, Ilhan
dc.contributor.authorInal, Ebrar
dc.contributor.authorKartal, Murat
dc.contributor.authorSucu, Melike
dc.contributor.authorIcen, Mehmet Sina
dc.date.accessioned2026-04-04T13:37:42Z
dc.date.available2026-04-04T13:37:42Z
dc.date.issued2025
dc.departmentİnönü Üniversitesi
dc.description.abstractIn this present work, in vitro lipoxygenase (LOX) inhibitory activities of methanol extracts and different fractions of six Achillea species [A. biebersteinii, A. millefolium, A. cappadocica, A. wilhelmsii, A. setacea, and A. nobilis subsp. neilreichii] were evaluated. A microplate-based spectrophotometric method was utilized for the LOX assay. The phenolic composition was analyzed using the liquid chromatography-high resolution mass spectrometer (LC-HRMS). As a result, the A. biebersteinii (Malatya locality) ethyl acetate fraction showed the highest lipoxygenase inhibitory activity (72.9% inhibition), followed by the A. cappadocica ethyl acetate fractions with 66.9% and 60.4% inhibition, respectively. The phytochemical LC-HRMS analyses revealed that the active constituents of the studied fractions were vanillic acid, hyperoside, p-coumaric acid, quercetin, and chrysoeriol. The findings showed the active bioassay-directed fractions, as well compounds to the best of our knowledge for the first time, suggesting further future biological, pharmacological, and toxicological evaluations both in vitro and in vivo.
dc.identifier.doi10.1002/cbdv.202500466
dc.identifier.issn1612-1872
dc.identifier.issn1612-1880
dc.identifier.issue10
dc.identifier.orcid0000-0003-1497-3017
dc.identifier.orcid0000-0002-3670-0899
dc.identifier.orcid0000-0002-1411-7184
dc.identifier.orcid0000-0002-6022-1644
dc.identifier.orcid0000-0002-7594-5178
dc.identifier.orcid0000-0002-1524-3617
dc.identifier.orcid0000-0002-1138-3145
dc.identifier.pmid40434967
dc.identifier.scopus2-s2.0-105007091950
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1002/cbdv.202500466
dc.identifier.urihttps://hdl.handle.net/11616/109995
dc.identifier.volume22
dc.identifier.wosWOS:001498014500001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley-V C H Verlag Gmbh
dc.relation.ispartofChemistry & Biodiversity
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250329
dc.subjectAchillea
dc.subjectanti-inflammatory activity
dc.subjecthyperoside
dc.subjectlipoxygenase
dc.subjectvanillic acid
dc.titleAnti-lipoxygenase Evaluation of Different Achillea sp. Extracts
dc.typeArticle

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