Coumarin or benzoxazinone based novel carbonic anhydrase inhibitors synthesis molecular docking and anticonvulsant studies

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dc.authoridTR120424en_US
dc.authoridTR38542en_US
dc.authoridTR195285en_US
dc.authoridTR112389en_US
dc.authoridTR6993en_US
dc.authoridTR29091en_US
dc.authoridTR5067en_US
dc.contributor.authorKarataş, Mert Olgun
dc.contributor.authorUslu, Harun
dc.contributor.authorSarı, Suat
dc.contributor.authorAlagöz, Mehmet Abdullah
dc.contributor.authorKarakurt, Arzu
dc.contributor.authorAlıcı, Bülent
dc.contributor.authorBilen, Çiğdem
dc.contributor.authorYavuz, Emre
dc.contributor.authorGençer, Nahit
dc.contributor.authorArslan, Oktay
dc.date.accessioned2017-04-12T11:30:51Z
dc.date.available2017-04-12T11:30:51Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAmong many others, coumarin derivatives are known to show human carbonic anhydrase (hCA) inhibitory activity. Since hCA inhibition is one of the underlying mechanisms that account for the activities of some antiepileptic drugs (AEDs), hCA inhibitors are expected to have antiseizure properties. There are also several studies reporting compounds with an imidazole and/or benzimidazole moiety which exert these pharmacological properties. In this study, we prepared fifteen novel coumarin-bearing imidazolium and benzimidazolium chloride, nine novel benzoxazinone-bearing imidazolium and benzimidazolium chloride derivatives and evaluated their hCA inhibitory activities and along with fourteen previously synthesized derivatives we scanned their anticonvulsant effects. As all compounds inhibited purified hCA isoforms I and II, some of them also proved protective against Maximal electroshock seizure (MES) and ScMet induced seizures in mice. Molecular docking studies with selected coumarin derivatives have revealed that these compounds bind to the active pocket of the enzyme in a similar fashion to that previously described for coumarin derivatives.en_US
dc.identifier.citationKarataş, M. O. Uslu, H. Sarı, S. Alagöz, M. A. Karakurt, A. Alıcı, B. Bilen, Ç. Yavuz, E. Gençer, N. Arslan, O. (2016). Coumarin or benzoxazinone based novel carbonic anhydrase inhibitors synthesis molecular docking and anticonvulsant studies. Journal of Enzyme Inhibition and Medicinal Chemistry, 31(5), 760–772.en_US
dc.identifier.doi10.3109/14756366.2015.1063624en_US
dc.identifier.endpage772en_US
dc.identifier.issn1475-6366
dc.identifier.issue5en_US
dc.identifier.startpage760en_US
dc.identifier.urihttp://www.tandfonline.com/doi/full/10.3109/14756366.2015.1063624
dc.identifier.urihttps://hdl.handle.net/11616/6648
dc.identifier.volume31en_US
dc.language.isoenen_US
dc.publisherJournal of Enzyme Inhibition and Medicinal Chemistryen_US
dc.relation.ispartofJournal of Enzyme Inhibition and Medicinal Chemistryen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAnticonvulsanten_US
dc.subjectBenzoxazinoneen_US
dc.subjectCarbonic anhydraseen_US
dc.subjectCoumarinen_US
dc.subjectEpilepsyen_US
dc.subjectİnhibitionen_US
dc.titleCoumarin or benzoxazinone based novel carbonic anhydrase inhibitors synthesis molecular docking and anticonvulsant studiesen_US
dc.typeArticleen_US

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