Novel Electrochemical Approaches for Anticancer Drug Monitoring: Application of CoS@Nitrogen-Doped Amorphous Porous Carbon Composite in Nilotinib Detection
Küçük Resim Yok
Tarih
2024
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Amer Chemical Soc
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
A novel composite containing CoS and nitrogen-doped amorphous porous carbon (NAPC), denoted as CoS@NAPC, was successfully synthesized from a mixture of cobalt-based ZIF-12 and sulfur through one-pot pyrolysis. The morphology and microstructure of the composites are evaluated with appropriate spectroscopic techniques. CoS@NAPC was used to modify the glassy carbon electrode (GCE) to detect Nilotinib. Under optimized conditions, the GCE electrode modified with CoS@NAPC showed a low limit of detection (LOD) of 11.8 ng/mL and two wide linear concentration ranges of 59.7-1570 and 1570-11200 ng/mL for the determination of Nilotinib. GCE electrode modified with CoS@NAPC has excellent recoveries ranging from 98.41 to 102.03% for real samples, demonstrating its superior analytical performance. The enhanced performance of CoS@NAPC as an electrochemical sensor may stem from the combined action of two key components: CoS, known for its potent reactivity toward Nilotinib, and NAPC, which offers a consistent conductive carbon matrix. CoS contributes to its reactivity, while NAPC facilitates electron transfer during Nilotinib detection. This synergistic effect likely underlies the superior sensor performance observed.
Açıklama
Anahtar Kelimeler
Performance Liquid-Chromatography, Tyrosine Kinase Inhibitors, Formation Mechanism, Imatinib, Nanoparticles, Electrodes, Lithium, Urine, Nanohybrids, Biosensors
Kaynak
Acs Omega
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
10
Sayı
1
