Novel Electrochemical Approaches for Anticancer Drug Monitoring: Application of CoS@Nitrogen-Doped Amorphous Porous Carbon Composite in Nilotinib Detection

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dc.contributor.authorYildir, Merve
dc.contributor.authorGenc, Asena Ayse
dc.contributor.authorBugday, Nesrin
dc.contributor.authorErk, Nevin
dc.contributor.authorPeighambardoust, Naeimeh Sadat
dc.contributor.authorAydemir, Umut
dc.contributor.authorYasar, Sedat
dc.date.accessioned2026-04-04T13:34:43Z
dc.date.available2026-04-04T13:34:43Z
dc.date.issued2024
dc.departmentİnönü Üniversitesi
dc.description.abstractA novel composite containing CoS and nitrogen-doped amorphous porous carbon (NAPC), denoted as CoS@NAPC, was successfully synthesized from a mixture of cobalt-based ZIF-12 and sulfur through one-pot pyrolysis. The morphology and microstructure of the composites are evaluated with appropriate spectroscopic techniques. CoS@NAPC was used to modify the glassy carbon electrode (GCE) to detect Nilotinib. Under optimized conditions, the GCE electrode modified with CoS@NAPC showed a low limit of detection (LOD) of 11.8 ng/mL and two wide linear concentration ranges of 59.7-1570 and 1570-11200 ng/mL for the determination of Nilotinib. GCE electrode modified with CoS@NAPC has excellent recoveries ranging from 98.41 to 102.03% for real samples, demonstrating its superior analytical performance. The enhanced performance of CoS@NAPC as an electrochemical sensor may stem from the combined action of two key components: CoS, known for its potent reactivity toward Nilotinib, and NAPC, which offers a consistent conductive carbon matrix. CoS contributes to its reactivity, while NAPC facilitates electron transfer during Nilotinib detection. This synergistic effect likely underlies the superior sensor performance observed.
dc.description.sponsorshipScientific Research Projects Coordination Unit of Ankara University [TSA-2023-2738]; Scientific Research Project Office of Ankara University (A.U. BAP) [TDK-2023-3036/TDK-2023-3039/TDK-2023-3126]; BAP Unit of Inonu University [FBG-2023-3310]
dc.description.sponsorshipThis work was supported by the Scientific Research Projects Coordination Unit of Ankara University with the Project Number TSA-2023-2738, the Scientific Research Project Office of Ankara University (A.U. BAP) (Project No. TDK-2023-3036/TDK-2023-3039/TDK-2023-3126), and the BAP Unit of Inonu University with the Project Number FBG-2023-3310.
dc.identifier.doi10.1021/acsomega.4c05505
dc.identifier.endpage271
dc.identifier.issn2470-1343
dc.identifier.issue1
dc.identifier.orcid0000-0002-2991-5488
dc.identifier.orcid0000-0001-5366-9275
dc.identifier.orcid0000-0001-7285-2761
dc.identifier.pmid39829576
dc.identifier.scopus2-s2.0-85214997033
dc.identifier.scopusqualityQ1
dc.identifier.startpage261
dc.identifier.urihttps://doi.org/10.1021/acsomega.4c05505
dc.identifier.urihttps://hdl.handle.net/11616/109362
dc.identifier.volume10
dc.identifier.wosWOS:001387418800001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAmer Chemical Soc
dc.relation.ispartofAcs Omega
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250329
dc.subjectPerformance Liquid-Chromatography
dc.subjectTyrosine Kinase Inhibitors
dc.subjectFormation Mechanism
dc.subjectImatinib
dc.subjectNanoparticles
dc.subjectElectrodes
dc.subjectLithium
dc.subjectUrine
dc.subjectNanohybrids
dc.subjectBiosensors
dc.titleNovel Electrochemical Approaches for Anticancer Drug Monitoring: Application of CoS@Nitrogen-Doped Amorphous Porous Carbon Composite in Nilotinib Detection
dc.typeArticle

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