Adrenomedullin administration alters vascular endothelial growth factor levels in rats in cold stress
Küçük Resim Yok
Tarih
2010
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Chulalongkorn Univ, Fac Med
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Background: Many endogenous peptides play important regulatory roles in angiogenesis by modulating endothelial cell behavior. Adrenomedullin (AdM) is one of such factors. Angiogenesis and vascular endothelial growth factor (VEGF) are indistinguishable. Exposure to cold environment stimulates capillary angiogenesis. Objectives: Examine the effect of the bioactive peptide AdM on VEGF levels in rat liver, lung, brain, and heart tissues after cold stress treatment. Methods: Male wistar rats were divided into four groups as control, AdM treatment, cold stress and AdM+cold stress treated groups. In AdM-treated group, animals received intraperitoneal injection of AdM (2000 ng/kg body weight) once a day during a week. For the cold stress exposure, the rats were kept in separate cages at 10 degrees C for a week. Results: The administration of AdM increased VEGF levels in all tissues in cold exposed rats. Conclusion: AdM may be a major regulatory factor in angiogenesis by modulating VEGF levels that is closely associated with cold exposure-related metabolic stimulation.
Açıklama
Anahtar Kelimeler
Adrenomedullin, angiogenesis, cold stress, rat, vascular endothelial growth factor (VEGF)
Kaynak
Asian Biomedicine
WoS Q Değeri
Q4
Scopus Q Değeri
N/A
Cilt
4
Sayı
6
