Adrenomedullin administration alters vascular endothelial growth factor levels in rats in cold stress

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dc.authoridYurekli, Muhittin/0000-0002-5830-8564
dc.authorwosidYurekli, Muhittin/B-4414-2016
dc.contributor.authorYildirim, Nuran Cikcikoglu
dc.contributor.authorYurekli, Muhittin
dc.date.accessioned2024-08-04T20:37:22Z
dc.date.available2024-08-04T20:37:22Z
dc.date.issued2010
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Many endogenous peptides play important regulatory roles in angiogenesis by modulating endothelial cell behavior. Adrenomedullin (AdM) is one of such factors. Angiogenesis and vascular endothelial growth factor (VEGF) are indistinguishable. Exposure to cold environment stimulates capillary angiogenesis. Objectives: Examine the effect of the bioactive peptide AdM on VEGF levels in rat liver, lung, brain, and heart tissues after cold stress treatment. Methods: Male wistar rats were divided into four groups as control, AdM treatment, cold stress and AdM+cold stress treated groups. In AdM-treated group, animals received intraperitoneal injection of AdM (2000 ng/kg body weight) once a day during a week. For the cold stress exposure, the rats were kept in separate cages at 10 degrees C for a week. Results: The administration of AdM increased VEGF levels in all tissues in cold exposed rats. Conclusion: AdM may be a major regulatory factor in angiogenesis by modulating VEGF levels that is closely associated with cold exposure-related metabolic stimulation.en_US
dc.identifier.doi10.2478/abm-2010-0126
dc.identifier.endpage958en_US
dc.identifier.issn1905-7415
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-84871678017en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage955en_US
dc.identifier.urihttps://doi.org/10.2478/abm-2010-0126
dc.identifier.urihttps://hdl.handle.net/11616/95899
dc.identifier.volume4en_US
dc.identifier.wosWOS:000285736000017en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherChulalongkorn Univ, Fac Meden_US
dc.relation.ispartofAsian Biomedicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAdrenomedullinen_US
dc.subjectangiogenesisen_US
dc.subjectcold stressen_US
dc.subjectraten_US
dc.subjectvascular endothelial growth factor (VEGF)en_US
dc.titleAdrenomedullin administration alters vascular endothelial growth factor levels in rats in cold stressen_US
dc.typeArticleen_US

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