The protective effects of apocynin on kidney damage caused by renal ischemia reperfusion

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dc.authoridTR179683en_US
dc.authoridTR100549en_US
dc.authoridTR45132en_US
dc.authoridTR107981en_US
dc.authoridTR105668en_US
dc.authoridTR58662en_US
dc.authoridTR102000en_US
dc.contributor.authorAltıntaş, Ramazan
dc.contributor.authorPolat, Alaadin
dc.contributor.authorVardı, Nigar
dc.contributor.authorBeytur, Ali
dc.contributor.authorYıldız, Azibe
dc.contributor.authorSağır, Mustafa
dc.contributor.authorParlakpınar, Hakan
dc.contributor.authorOğuz, Fatih
dc.date.accessioned2017-04-11T11:58:33Z
dc.date.available2017-04-11T11:58:33Z
dc.date.issued2013
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPurpose: This experimental study was designed to explore the protective effect of apocynin, the NADPH-oxidase inhibitor, on kidney damage induced by ischemia/reperfusion (I/R) in a rat model. Methods: Thirty-two rats were randomly divided into a control group and three I/R groups (1-hour ischemia followed by 23-hour reperfusion). Three I/R groups were treated by apocynin (20 mg/kg, i.p.) at two different time points (before ischemia and during ischemia). The histopathological findings, including apoptotic changes, and also tissue malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), glutathion peroxidase (GPX), reduced glutathione (GSH), myeloperoxidase (MPO), blood urea nitrogen (BUN), and serum creatinine (Cr) levels, were determined. Results: Kidney tissue MDA and MPO, and serum BUN and Cr levels were found to be significantly higher in the I/R group, but there was no statistically significant difference in the levels of SOD, CAT, GPX, and GSH between the I/R and the control groups. Although apocynin significantly reduced MDA and MPO in group 3 and increased GPX in both treatment groups when compared to the I/R group, the elevated BUN and Cr levels were significantly reduced in treatment groups. Renal I/R injury also induced extensive tubular necrosis, glomerular damage, and apoptosis in the histological evaluation. Apocynin, especially when used during ischemia, ameliorated these histological damages in different amounts in treatment groups. Conclusion: The beneficial effects of apocynin on renal I/R injury were evaluated for the first time.en_US
dc.identifier.citationAltıntaş, R. Polat, A. Vardı, N. Beytur, A. Yıldız, A. Sağır, M. Parlakpınar, H. Oğuz, F. (2013). The Protective Effects of Apocynin on Kidney Damage Caused by Renal Ischemia Reperfusion. Journal of Endourology, 27(5), 617–624.en_US
dc.identifier.doi10.1089/end.2012.0556en_US
dc.identifier.endpage624en_US
dc.identifier.issn0892-7790
dc.identifier.issue5en_US
dc.identifier.startpage617en_US
dc.identifier.urihttp://online.liebertpub.com/doi/abs/10.1089/end.2012.0556
dc.identifier.urihttps://hdl.handle.net/11616/6639
dc.identifier.volume27en_US
dc.language.isoenen_US
dc.publisherJournal of Endourologyen_US
dc.relation.ispartofJournal of Endourologyen_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.titleThe protective effects of apocynin on kidney damage caused by renal ischemia reperfusionen_US
dc.typeArticleen_US

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