Matrix metalloproteinase 9 gene-MMP9-DNA methylation status in Turkish schizophrenia patients

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dc.authoridGozukara Bag, Harika Gozde/0000-0003-1208-4072
dc.authoridAcar, Ceren/0000-0003-1842-9203
dc.authoridKaraaslan, Ezgi/0000-0003-1865-4937
dc.authorwosidGozukara Bag, Harika Gozde/ABG-7588-2020
dc.authorwosidAcar, Ceren/M-2926-2019
dc.contributor.authorKaraaslan, Ezgi
dc.contributor.authorKartalci, Sukru
dc.contributor.authorBag, Harika Gozde Gozukara
dc.contributor.authorAcar, Ceren
dc.date.accessioned2024-08-04T20:53:30Z
dc.date.available2024-08-04T20:53:30Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjectives: Schizophrenia is a neuropsychiatric disease caused by disorders in brain development due to genetic and environmental factors. The interactions and mechanisms of the two main etiological factors are not fully understood despite neurobiological, clinical and genetic research and more research is needed. In this study, we aimed to investigate the DNA methylation differences in the matrix metalloproteinase 9 gene (MMP9) between schizophrenia and healthy control groups.Methods: Our study investigates DNA methylation patterns in the MMP9 gene in peripheral blood cells of schizophrenia patients. For this purpose, pyrosequencing method was used to analyze DNA methylation status of C-phosphate-G (CpG) regions in the 7th exon of MMP9 in 40 schizophrenia patients and 32 healthy individuals who admitted to our university hospital's psychiatry clinic.Results: In our results, it has been shown that there is a difference between MMP9 gene DNA methylations between healthy individuals and schizophrenia patients. Significant differences were found in the MMP9 gene exon 7 region in CpG 7-3, CpG 7-4, CpG 7-5 positions and mean methylation patterns between these two groups. Conclusions: This study provided evidence that DNA methylation differences may exist between schizophrenia patients and healthy individuals, and emphasized the epigenetic aspect of the disorder.en_US
dc.description.sponsorshipInonu University Scientific Research Projects Unit [FYL-2020-2241]en_US
dc.description.sponsorshipThe present study is supported by Inonu University Scientific Research Projects Unit grant # FYL-2020-2241en_US
dc.identifier.doi10.1515/tjb-2022-0215
dc.identifier.endpage79en_US
dc.identifier.issn0250-4685
dc.identifier.issn1303-829X
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85149070482en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage74en_US
dc.identifier.urihttps://doi.org/10.1515/tjb-2022-0215
dc.identifier.urihttps://hdl.handle.net/11616/101196
dc.identifier.volume48en_US
dc.identifier.wosWOS:000933174100001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWalter De Gruyter Gmbhen_US
dc.relation.ispartofTurkish Journal of Biochemistry-Turk Biyokimya Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDNA methylationen_US
dc.subjectepigeneticen_US
dc.subjectMMP9en_US
dc.subjectpyrosequencingen_US
dc.subjectschizophreniaen_US
dc.titleMatrix metalloproteinase 9 gene-MMP9-DNA methylation status in Turkish schizophrenia patientsen_US
dc.typeArticleen_US

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