Moderate/High-Intensity Exercise and Coenzyme Q10 Supplementation May Reduce Tumstatin and Improve the Lipid Dynamics and Body Mass in Rats
Küçük Resim Yok
Tarih
2025
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Mdpi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Coenzyme Q(10) (CoQ(10)) is a molecule that serves as a coenzyme for mitochondrial enzymes, playing a fundamental role in mitochondrial bioenergetics as an electron and proton carrier in the energy production process. This study aimed to examine the modulatory effects of moderate/high-intensity exercise and CoQ(10) supplementation on tumstatin, lipid dynamics, and body mass in rats. This study used 42 male Wistar Albino rats in six groups: a control group (C), a moderate-intensity continuous training group (MICT), a high-intensity continuous training group (HICT), a coenzyme Q(10) group (Q(10)), a moderate-intensity continuous training combined with Q(10) group (MICTQ(10)), and a high-intensity continuous training combined with Q(10) group (HICTQ(10)) to assess the effects of exercise and 5 mg/kg/daily CoQ(10) supplementation. Rats underwent treadmill training, and tumstatin levels in plasma, cardiac, and skeletal muscle tissues were measured using ELISA and immunostaining techniques. In addition to the plasma, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), and total cholesterol (TC) levels were analyzed using enzymatic methods, with the LDL-C calculated using the Friedewald equation. The atherogenic index of plasma was determined by the TG/HDL-C ratio. As compared to group C, body mass was significantly affected by both exercise intensity and supplementation (p = 0.01, eta(2) = 0.37), with the MICTQ(10) and HICTQ(10) groups demonstrating the greatest reductions by day 50th (p = 0.0003, d = 4.02; p = 0.0001, d = 3.99). Lipid profiles varied significantly between groups. Compared to the C group, the MICTQ(10) group exhibited the most substantial decreases in LDL-C (p = 0.03, d = 2.35) and TG levels (p = 0.03, d = 2.25), while the HICTQ(10) group showed the most pronounced reduction in TC levels (p = 0.001, d = 6.41). Regarding tumstatin levels, skeletal muscle tumstatin levels were lowest in the HICTQ(10) group (p = 0.01, d = 2.11). Moreover, cardiac muscle tumstatin levels were significantly lower in the MICTQ(10), MICT, and HICTQ(10) groups compared to in the C group (p = 0.004, d = 1.01). These findings suggest that both exercise intensity and CoQ(10) supplementation exert notable physiological effects, particularly in modulating body mass, lipid metabolism, and tumstatin levels.
Açıklama
Anahtar Kelimeler
body mass, CoQ(10), Col-IV alpha 3, HICT, lipid, MICT, tumstatin
Kaynak
Applied Sciences-Basel
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
15
Sayı
5
