Moderate/High-Intensity Exercise and Coenzyme Q10 Supplementation May Reduce Tumstatin and Improve the Lipid Dynamics and Body Mass in Rats

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dc.contributor.authorYasul, Yavuz
dc.contributor.authorAkcinar, Faruk
dc.contributor.authorCinar, Vedat
dc.contributor.authorAkbulut, Taner
dc.contributor.authorAydemir, Isa
dc.contributor.authorYalcin, Mehmet Hanifi
dc.contributor.authorAvcu, Emsal cagla
dc.date.accessioned2026-04-04T13:31:13Z
dc.date.available2026-04-04T13:31:13Z
dc.date.issued2025
dc.departmentİnönü Üniversitesi
dc.description.abstractCoenzyme Q(10) (CoQ(10)) is a molecule that serves as a coenzyme for mitochondrial enzymes, playing a fundamental role in mitochondrial bioenergetics as an electron and proton carrier in the energy production process. This study aimed to examine the modulatory effects of moderate/high-intensity exercise and CoQ(10) supplementation on tumstatin, lipid dynamics, and body mass in rats. This study used 42 male Wistar Albino rats in six groups: a control group (C), a moderate-intensity continuous training group (MICT), a high-intensity continuous training group (HICT), a coenzyme Q(10) group (Q(10)), a moderate-intensity continuous training combined with Q(10) group (MICTQ(10)), and a high-intensity continuous training combined with Q(10) group (HICTQ(10)) to assess the effects of exercise and 5 mg/kg/daily CoQ(10) supplementation. Rats underwent treadmill training, and tumstatin levels in plasma, cardiac, and skeletal muscle tissues were measured using ELISA and immunostaining techniques. In addition to the plasma, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), and total cholesterol (TC) levels were analyzed using enzymatic methods, with the LDL-C calculated using the Friedewald equation. The atherogenic index of plasma was determined by the TG/HDL-C ratio. As compared to group C, body mass was significantly affected by both exercise intensity and supplementation (p = 0.01, eta(2) = 0.37), with the MICTQ(10) and HICTQ(10) groups demonstrating the greatest reductions by day 50th (p = 0.0003, d = 4.02; p = 0.0001, d = 3.99). Lipid profiles varied significantly between groups. Compared to the C group, the MICTQ(10) group exhibited the most substantial decreases in LDL-C (p = 0.03, d = 2.35) and TG levels (p = 0.03, d = 2.25), while the HICTQ(10) group showed the most pronounced reduction in TC levels (p = 0.001, d = 6.41). Regarding tumstatin levels, skeletal muscle tumstatin levels were lowest in the HICTQ(10) group (p = 0.01, d = 2.11). Moreover, cardiac muscle tumstatin levels were significantly lower in the MICTQ(10), MICT, and HICTQ(10) groups compared to in the C group (p = 0.004, d = 1.01). These findings suggest that both exercise intensity and CoQ(10) supplementation exert notable physiological effects, particularly in modulating body mass, lipid metabolism, and tumstatin levels.
dc.description.sponsorshipInonu University Scientific Research Projects Coordination Unit; [2209]
dc.description.sponsorshipThis study was supported by the Inonu University Scientific Research Projects Coordination Unit (Project Number: 2209).
dc.identifier.doi10.3390/app15052618
dc.identifier.issn2076-3417
dc.identifier.issue5
dc.identifier.orcid0000-0002-2156-6236
dc.identifier.orcid0000-0002-9458-1664
dc.identifier.orcid0000-0002-9458-1664
dc.identifier.orcid0000-0003-2924-5848
dc.identifier.orcid0000-0003-2500-1117
dc.identifier.orcid0000-0003-2751-1743
dc.identifier.scopus2-s2.0-86000572652
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3390/app15052618
dc.identifier.urihttps://hdl.handle.net/11616/108665
dc.identifier.volume15
dc.identifier.wosWOS:001442602800001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofApplied Sciences-Basel
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250329
dc.subjectbody mass
dc.subjectCoQ(10)
dc.subjectCol-IV alpha 3
dc.subjectHICT
dc.subjectlipid
dc.subjectMICT
dc.subjecttumstatin
dc.titleModerate/High-Intensity Exercise and Coenzyme Q10 Supplementation May Reduce Tumstatin and Improve the Lipid Dynamics and Body Mass in Rats
dc.typeArticle

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