Assessment of antioxidant, acetylcholinesterase, paraoxonase inhibition activities and phenolic content of Alchemilla lithophila

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dc.authoridGÜZEL, Abdussamat/0000-0001-7810-4510
dc.authorwosidGÜZEL, Abdussamat/GXG-4734-2022
dc.contributor.authorGuzel, Abdussamat
dc.date.accessioned2024-08-04T20:55:05Z
dc.date.available2024-08-04T20:55:05Z
dc.date.issued2024
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn the present study, antioxidant activity and inhibition of acetylcholinesterase (AChE) and paraoxonase (hPON 1) of Alchemilla lithophila extracts were evaluated for the first time. Besides, there is no research on the contents of phenolic compounds except for fatty acids. In this context, phenolic compounds of A. lithophila were investigated by liquid chromatography/ mass spectrometry (LC-MS/MS). The methanol extract of the A. lithophila exhibited significant inhibition on the AChE (IC50 value for methanol extract 0.162 +/- 0.25 mg /mL, R-2 :0.992). Besides, antioxidant activities of the A. lithophila extracts were examined using by the methods ABTS(center dot+)and DPPH center dot free radical scavenging potentials, FRAP and CUPRAC metal-reducing activities. ABTS(center dot+) and DPPH center dot scavenging activities were found for methanol extract at 70.67% and water extract at 75.38%, respectively. Also, FRAP and CUPRAC metal-reducing were determined for water extract 0.796 and hexane extract 1.570 as absorbance. According to LC-MS/MS analyses, the amounts of ellagic acid, catechin hydrate, gallic acid, fumaric acid, luteolin, quercetin, kaempferol, acetohydroxamic acid, caffeic acid, syringic acid, hydroxybenzoic acid and salicylic acid were determined by LC-MS/MS, respectively. As a consequence, this study will be a useful resource for determining bioactivity and phenolic compound profile for natural medicine research.en_US
dc.description.sponsorshipInonu University Faculty of Science Department of Chemistryen_US
dc.description.sponsorshipThe author thanks the Inonu University Faculty of Science Department of Chemistry for the spectroscopy data and bioactivity studies.en_US
dc.identifier.doi10.36721/PJPS.2024.37.1.REG.025-032.1
dc.identifier.endpage32en_US
dc.identifier.issn1011-601X
dc.identifier.issue1en_US
dc.identifier.pmid38741397en_US
dc.identifier.scopus2-s2.0-85184865273en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage25en_US
dc.identifier.urihttps://doi.org/10.36721/PJPS.2024.37.1.REG.025-032.1
dc.identifier.urihttps://hdl.handle.net/11616/101814
dc.identifier.volume37en_US
dc.identifier.wosWOS:001168141900013en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherUniv Karachien_US
dc.relation.ispartofPakistan Journal of Pharmaceutical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcetylcholinesteraseen_US
dc.subjectparaoxonaseen_US
dc.subjectantioxidanten_US
dc.subjectAlchemilla lithophilaen_US
dc.subjectLC-MS/MSen_US
dc.titleAssessment of antioxidant, acetylcholinesterase, paraoxonase inhibition activities and phenolic content of Alchemilla lithophilaen_US
dc.typeArticleen_US

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