Protective effects of ghrelin on kidney tissue in rats with partial ureteral obstruction

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dc.authoridAteş, Burhan/0000-0001-6080-229X
dc.authoridVardı, Nigar/0000-0003-0576-1696
dc.authorwosidCimen, Serhan/X-4007-2018
dc.authorwosidAteş, Burhan/AAA-3730-2021
dc.authorwosidVardı, Nigar/C-9549-2018
dc.contributor.authorCimen, Serhan
dc.contributor.authorTasdemir, Cemal
dc.contributor.authorVardi, Nigar
dc.contributor.authorAtes, Burhan
dc.contributor.authorTasdemir, Seda
dc.contributor.authorOzaydogdu Cimen, Ayla
dc.date.accessioned2024-08-04T20:09:58Z
dc.date.available2024-08-04T20:09:58Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground/aim: The aim was to investigate the protective and therapeutic effects of ghrelin, which has antioxidant and antiinflammatory activity, on preventing kidney damage that occurs by induced partial ureteral obstruction in rats. Materials and methods: Twenty-eight adult male rats were included in the study, and the rats were divided into 4 groups. After the laparotomy operation on the sham group, the ureter was identified in the retroperitoneal area and was duly sutured (n = 7). Ghrelin was administered for seven days intraperitoneally, and after the nephrectomy performed on the 15th day, the rats were sacrificed (n = 7). A partial ureteral obstruction was performed after the laparotomy on the PUO group. The rats were sacrificed after the nephrectomy operation performed on the 15th day (n = 7). A partial ureteral obstruction was formed after the laparotomy followed by seven days of waiting in the PUO i ghrelin group. Ghrelin was given in the dose of 10 ng/kg per day intraperitoneally for the next 7 days, and the rats were sacrificed after the nephrectomy operation performed on the 15th day (n = 7). All groups were evaluated for histological damage and catalase, superoxide dismutase, total glutathione, malondialdehyde, and myeloperoxidase levels were measured in the same tissues. Results: When the 2nd group and the sham group were compared histologically, it was observed that the damage had increased by a statistically significant level in the partial ureteral obstruction group (P 0.001). When the group which was ghrelin-treated after the partial ureteral obstruction was compared to the group with just partial ureteral obstruction, the histopathological changes were found to decrease significantly in that group (P = 0.001). While the statistical significance of the levels of CAT, GSH, and MP() enzymes was detected among biochemical changes in the 2nd group when compared to the sham group (P < 0.01), the 3rd group showed a statistically significant difference in the levels of SOD and GSH enzymes compared to the 4th group (P < 0.05). Conclusion: Ghrelin administration to rats after the formation of an experimental partial unilateral ureteral obstruction reduces tissue damage due to ghrelin's antiinflammatory and antioxidant effects. Ghrelin administration may prevent tissue damage biochemically and histopathologically in obstructive uropathy cases.en_US
dc.description.sponsorshipScientific Research Fund of Inonu University [2013/194]en_US
dc.description.sponsorshipThis study was supported by a grant from the Scientific Research Fund of Inonu University (Project Number: 2013/194).en_US
dc.identifier.doi10.3906/sag-1802-17
dc.identifier.endpage702en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue2en_US
dc.identifier.pmid30997983en_US
dc.identifier.scopus2-s2.0-85065027543en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage696en_US
dc.identifier.trdizinid336111en_US
dc.identifier.urihttps://doi.org/10.3906/sag-1802-17
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/336111
dc.identifier.urihttps://hdl.handle.net/11616/92531
dc.identifier.volume49en_US
dc.identifier.wosWOS:000465264700035en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technological Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPartial ureteral obstructionen_US
dc.subjectghrelinen_US
dc.subjectprotective effecten_US
dc.subjectkidneyen_US
dc.titleProtective effects of ghrelin on kidney tissue in rats with partial ureteral obstructionen_US
dc.typeArticleen_US

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