Contribution of Polymorphism in PPAR? Untranslated Region to The Development of Axial Spondyloarthritis

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dc.contributor.authorAKBULUT, EKREM
dc.contributor.authorÖZGEN, Metin
dc.date.accessioned2022-10-26T08:42:45Z
dc.date.available2022-10-26T08:42:45Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractÖz: The study aimed to contribute to the overall understanding of axial spondyloarthritis by investigating the polymorphism in 5’ untranslated region of peroxisome proliferator-activated receptor alpha gene in patients. The study included 194 patients and 197 controls recruited. The DNA obtained from the samples was genotyped by multiplex Polymerase Chain Reaction and then Matrix-Assisted Laser Desorption Ionization- Time of Flight Mass Spectrometry. Data were analyzed by logistic regression. Five polymorphic regions analyzed in this study, three of the sites were associated with disease risk. An allele in the rs1800204 polymorphic region (p < 0.001), C allele in the rs4253657 polymorphic region (p = 0.040) and C allele in the rs13909022 polymorphic region (p = 0.005) were associated with disease risk. The association of disease risk could not be detected with G and A alleles in the rs881740 (p = 0.456) and rs115640476 (p = 0.674) polymorphic regions, respectively. PPAR? 5' untranslated region polymorphism, which is shown to be associated with disease risk, is thought to contribute to the elucidation of the molecular mechanism of the disease. In axial spondyloarthritis, studying the effects of genetic changes in PPAR? on other genes with which it interacts will contribute to the full understanding of the molecular mechanism of the disease. Keywords: Axial spondyloarthritis; Peroxisome proliferator activated receptor alpha; Genetic predisposition; Disease risk.en_US
dc.identifier.citationAKBULUT E, ÖZGEN M (2020). Contribution of Polymorphism in PPARα Untranslated Region to The Development of Axial Spondyloarthritis. Adıyaman Üniversitesi Fen Bilimleri Dergisi, 10(1), 55 - 64. 10.37094/adyujsci.650677en_US
dc.identifier.doi10.37094/adyujsci.650677en_US
dc.identifier.endpage64en_US
dc.identifier.issn2147-1630
dc.identifier.issn2146-586X
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85126319853en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage55en_US
dc.identifier.trdizinid469458en_US
dc.identifier.urihttps://doi.org/10.37094/adyujsci.650677
dc.identifier.urihttps://hdl.handle.net/11616/85201
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/469458
dc.identifier.volume10en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofAdıyaman Üniversitesi Fen Bilimleri Dergisien_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleContribution of Polymorphism in PPAR? Untranslated Region to The Development of Axial Spondyloarthritisen_US
dc.typeArticleen_US

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