Hepatic Arginase - Nitric oxide imbalance: Impact of carcinogenesis and therapeutic effect of sodium channel blockage in an in vivo rat model

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dc.authoridUyumlu, Ayşe Burçin/0000-0001-9517-9274
dc.authoridSatilmis, Basri/0000-0002-2538-5774
dc.authoridBatcioglu, Kadir/0000-0001-6663-2287
dc.authoridSatilmis, Basri/0000-0002-2538-5774
dc.authoridGenç, Metin Fikret/0000-0002-6244-0517;
dc.authorwosidUyumlu, Ayşe Burçin/ABH-5573-2020
dc.authorwosidSatilmis, Basri/C-5176-2019
dc.authorwosidBatcioglu, Kadir/Q-2424-2015
dc.authorwosidSatilmis, Basri/JBR-9078-2023
dc.authorwosidGenç, Metin Fikret/ABI-2169-2020
dc.authorwosidBentli, Recep/AAB-4140-2021
dc.authorwosidDjamgoz, Mustafa/KJL-8515-2024
dc.contributor.authorBatcioglu, Kadir
dc.contributor.authorYildirim, Battal
dc.contributor.authorSatilmis, Basri
dc.contributor.authorUyumlu, Ayse Burcin
dc.contributor.authorGenc, Metin Fikret
dc.contributor.authorBentli, Recep
dc.contributor.authorDjamgoz, Mustafa B. A.
dc.date.accessioned2024-08-04T20:09:49Z
dc.date.available2024-08-04T20:09:49Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: Nitric oxide synthase and arginase are frequently antagonistic and interactive, although both use L-arginine as common substrate. Their balance is of potential functional importance. How the balance changes in cancer is unknown. Increasing evidence suggests that progression of carcinomas involves functional voltage-gated sodium channel (VGSC) activity. Methods: The present study extended this study to liver and aimed to determine whether (i) DMBA carcinogenesis would affect the activities of arginase and NOS and (ii) treatment with Na-channel blocker RS100642 would ameliorate the impact of the carcinogen on the arginase-NOS balance. Results: DMBA application significantly increased arginase activity and, correspondingly, the level of L-ornithine by 25-33%. In contrast, NOS activity decreased by 11%. Importantly, RS100642 treatment completely suppressed the effect on arginase. Conclusion: It is concluded (i) that DMBA carcinogenesis changes the hepatic arginase-NOS balance, increasing the overall dominance of arginase and (ii) that VGSC inhibition has a protective effect on liver.en_US
dc.description.sponsorshipScientific Research Coordination Department of Inonu University; Pro Cancer Research Fund (PCRF)en_US
dc.description.sponsorshipThis project was supported by a grant from the Scientific Research Coordination Department of Inonu University. The work on 'ion channels and cancer' at Imperial College London is supported by the Pro Cancer Research Fund (PCRF).en_US
dc.identifier.doi10.1515/tjb-2016-0040
dc.identifier.endpage279en_US
dc.identifier.issn0250-4685
dc.identifier.issn1303-829X
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-84982787930en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage275en_US
dc.identifier.trdizinid224911en_US
dc.identifier.urihttps://doi.org/10.1515/tjb-2016-0040
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/224911
dc.identifier.urihttps://hdl.handle.net/11616/92461
dc.identifier.volume41en_US
dc.identifier.wosWOS:000387205500007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherWalter De Gruyter Gmbhen_US
dc.relation.ispartofTurkish Journal of Biochemistry-Turk Biyokimya Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectLiveren_US
dc.subjectCarcinogenesisen_US
dc.subjectArginaseen_US
dc.subjectNitric oxide synthaseen_US
dc.subjectSodium channelsen_US
dc.subjectRS100642en_US
dc.titleHepatic Arginase - Nitric oxide imbalance: Impact of carcinogenesis and therapeutic effect of sodium channel blockage in an in vivo rat modelen_US
dc.typeArticleen_US

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