Antioxidant and cytotoxic properties of some new dipeptide-indole conjugates
Küçük Resim Yok
Tarih
2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wiley
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
In this study, 10 new indole-dipeptide conjugates were synthesized, and their anticancer activity was determined against on A2780 (ovarian cancer cell line) and MCF-7 (breast cancer cell line) cells. Among compounds, 5 and 10 showed better activity against A2780 cell lines than the standard drug docatexel at 0.1 and 1 mu M concentrations, while only compound 5 showed better activity than docatexel, the MCF-7 cell line at 0.1 and 1 mu M concentrations. The antioxidant potencies of the compounds were low in both the DPPH and iron reducing power methods tested when compared to standard antioxidants used in this work.
Açıklama
Anahtar Kelimeler
Rapid Colorimetric Assay, Anticancer Agents, Vinblastine, Survival, Scaffold, Growth
Kaynak
Journal of Heterocyclic Chemistry
WoS Q Değeri
Q2
Scopus Q Değeri
Q3
Cilt
60
Sayı
1
