Antioxidant and cytotoxic properties of some new dipeptide-indole conjugates

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dc.authoridTekin, Zehra/0000-0003-3682-3044
dc.authorwosidTEKİN, zehra/HSH-9254-2023
dc.authorwosidTekin, Zehra/GLR-6001-2022
dc.contributor.authorGonul, Zeynep
dc.contributor.authorOzturk, Dilara Altay
dc.contributor.authorKucukbay, Fatumetuzzehra
dc.contributor.authorTekin, Suat
dc.contributor.authorTekin, Zehra
dc.contributor.authorKucukbay, Hasan
dc.date.accessioned2024-08-04T20:52:18Z
dc.date.available2024-08-04T20:52:18Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn this study, 10 new indole-dipeptide conjugates were synthesized, and their anticancer activity was determined against on A2780 (ovarian cancer cell line) and MCF-7 (breast cancer cell line) cells. Among compounds, 5 and 10 showed better activity against A2780 cell lines than the standard drug docatexel at 0.1 and 1 mu M concentrations, while only compound 5 showed better activity than docatexel, the MCF-7 cell line at 0.1 and 1 mu M concentrations. The antioxidant potencies of the compounds were low in both the DPPH and iron reducing power methods tested when compared to standard antioxidants used in this work.en_US
dc.description.sponsorshipInonu University, Turkey [FOA-2020-2203]en_US
dc.description.sponsorshipInonu University, Turkey, Grant/Award Number: FOA-2020-2203en_US
dc.identifier.doi10.1002/jhet.4564
dc.identifier.endpage95en_US
dc.identifier.issn0022-152X
dc.identifier.issn1943-5193
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85137595024en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage86en_US
dc.identifier.urihttps://doi.org/10.1002/jhet.4564
dc.identifier.urihttps://hdl.handle.net/11616/100879
dc.identifier.volume60en_US
dc.identifier.wosWOS:000849881000001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Heterocyclic Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectRapid Colorimetric Assayen_US
dc.subjectAnticancer Agentsen_US
dc.subjectVinblastineen_US
dc.subjectSurvivalen_US
dc.subjectScaffolden_US
dc.subjectGrowthen_US
dc.titleAntioxidant and cytotoxic properties of some new dipeptide-indole conjugatesen_US
dc.typeArticleen_US

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