Inflammasomes and their regulation in oral diseases

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dc.authorscopusid56611741700
dc.authorscopusid9535750500
dc.contributor.authorAral K.
dc.contributor.authorMilward M.R.
dc.date.accessioned2024-08-04T20:03:55Z
dc.date.available2024-08-04T20:03:55Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe oral microbiome can initiate a range of bacterially driven diseases including caries and periodontal diseases. Among them, gingivitis and periodontitis are well-defined and common forms of periodontal diseases, being periodontitis is the progressive form of gingivitis and is associated with a range of systemic disease and driven by a hyperinflammatory phenotype. During periodontal inflammation, interleukin (IL)-1? activate endothelial cells and triggers adhesion of eosinophils increasing the inflammatory response. Several inflammasomes including Nod-like receptor (NLR) pyrin domain-containing protein 1 (NLRP1), NLRP2, NLRP3, NLR containing a caspase activating and recruitment domain (CARD) 4 (NLRC4) and Absent in melanoma 2 (AIM2) have been involved in the pathogenesis of periodontal diseases. Inflammasome modulation in diseases of the oral cavity is a potential novel therapeutic intervention for oral disease management. © 2023 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/B978-0-323-91802-2.00025-6
dc.identifier.endpage354en_US
dc.identifier.isbn9780323918022
dc.identifier.isbn9780323972062
dc.identifier.scopus2-s2.0-85199076799en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage343en_US
dc.identifier.urihttps://doi.org/10.1016/B978-0-323-91802-2.00025-6
dc.identifier.urihttps://hdl.handle.net/11616/92200
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofInflammasome Biology: Fundamentals, Role in Disease States, and Therapeutic Opportunitiesen_US
dc.relation.publicationcategoryKitap Bölümü - Uluslararasıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGingivitisen_US
dc.subjectHyperinflammationen_US
dc.subjectIL-1?en_US
dc.subjectInflammasomeen_US
dc.subjectOral microbiomeen_US
dc.subjectPeriodontal diseaseen_US
dc.subjectPeriodontitisen_US
dc.titleInflammasomes and their regulation in oral diseasesen_US
dc.typeBook Chapteren_US

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