Tryptophan Degradation and Antioxidant Status in Patients With Thyroid Disorders
Küçük Resim Yok
Tarih
2018
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Acad Medical Sciences I R Iran
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background: The aim of this study was to evaluate the degradation of tryptophan (Trp), neopterin production and antioxidant capacity in patients with benign and malignant thyroid disease. Methods: For this reason, the levels of tryptophan, kynurenine (Kyn) and neopterin, and superoxide disintitase (SOD) and catalase (CAT) enzyme activities in 67 thyroid patients were evaluated in our study and the results were compared with 30 healthy controls. Results: Tryptophan and kynurenine levels in thyroid patients decreased compared to the control group. Patients with thyroid disease had lower CAT activity than the control group. The neopterin and tryptophan levels in malignant and benign patients were also significantly different. Conclusion: The results of the present study suggest that thyroid disorders may lead to changes in tryptophan degradation, neopterin production and CAT enzyme activities.
Açıklama
Anahtar Kelimeler
Antioxidant enzymes, Indoleamine 2,3-Dioxygenase activity, Kynurenine, Neopterin, Thyroid diseases, Tryptophan
Kaynak
Archives of Iranian Medicine
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
21
Sayı
9
