Tryptophan Degradation and Antioxidant Status in Patients With Thyroid Disorders

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dc.authoridYuksel, Osman/0000-0001-9492-1756
dc.authoridÜnüvar, Songül/0000-0001-8454-490X
dc.authoridBAYDAR, Terken/0000-0002-5497-9600
dc.authoridSAHIN, TEVFIK TOLGA/0000-0002-9132-6115
dc.authorid, BAYDAR/0000-0002-5497-9600
dc.authorwosidBAYDAR, TERKEN/JAC-5447-2023
dc.authorwosidYuksel, Osman/GLR-3304-2022
dc.authorwosidÜnüvar, Songül/ABH-5516-2020
dc.authorwosidBAYDAR, Terken/JRY-1626-2023
dc.authorwosidSAHIN, TEVFIK TOLGA/AAA-9648-2021
dc.authorwosid, BAYDAR/J-1107-2013
dc.contributor.authorUnuvar, Songul
dc.contributor.authorGirgin, Gozde
dc.contributor.authorSahin, Tevfik Tolga
dc.contributor.authorKilicarslan, Bilge
dc.contributor.authorTaneri, Ferit
dc.contributor.authorYuksel, Osman
dc.contributor.authorBaydar, Terken
dc.date.accessioned2024-08-04T20:45:40Z
dc.date.available2024-08-04T20:45:40Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: The aim of this study was to evaluate the degradation of tryptophan (Trp), neopterin production and antioxidant capacity in patients with benign and malignant thyroid disease. Methods: For this reason, the levels of tryptophan, kynurenine (Kyn) and neopterin, and superoxide disintitase (SOD) and catalase (CAT) enzyme activities in 67 thyroid patients were evaluated in our study and the results were compared with 30 healthy controls. Results: Tryptophan and kynurenine levels in thyroid patients decreased compared to the control group. Patients with thyroid disease had lower CAT activity than the control group. The neopterin and tryptophan levels in malignant and benign patients were also significantly different. Conclusion: The results of the present study suggest that thyroid disorders may lead to changes in tryptophan degradation, neopterin production and CAT enzyme activities.en_US
dc.identifier.endpage405en_US
dc.identifier.issn1029-2977
dc.identifier.issn1735-3947
dc.identifier.issue9en_US
dc.identifier.pmid30221530en_US
dc.identifier.scopus2-s2.0-85059567980en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage399en_US
dc.identifier.urihttps://hdl.handle.net/11616/98597
dc.identifier.volume21en_US
dc.identifier.wosWOS:000444008400004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAcad Medical Sciences I R Iranen_US
dc.relation.ispartofArchives of Iranian Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntioxidant enzymesen_US
dc.subjectIndoleamine 2,3-Dioxygenase activityen_US
dc.subjectKynurenineen_US
dc.subjectNeopterinen_US
dc.subjectThyroid diseasesen_US
dc.subjectTryptophanen_US
dc.titleTryptophan Degradation and Antioxidant Status in Patients With Thyroid Disordersen_US
dc.typeArticleen_US

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