The protective effects of chrysin and flunixin meglumine against excess copper in male rats

Basit Öğe Kaydı
dc.authoridSeven, Pınar Tatlı/0000-0002-0067-4190
dc.authoridbasak, nese/0000-0001-5566-8321
dc.authoridSeven, İsmail/0000-0001-9489-8074
dc.authoridGul, Burcu/0000-0002-9122-8953
dc.authorwosidSeven, Pınar Tatlı/W-3676-2017
dc.authorwosidbasak, nese/ABH-5495-2020
dc.authorwosidSeven, İsmail/W-4077-2018
dc.authorwosidtatlı seven, pınar/W-2297-2018
dc.authorwosidGul, Burcu/V-9452-2018
dc.contributor.authorSeven, Pinar Tatli
dc.contributor.authorBaykalir, Burcu Gul
dc.contributor.authorSeven, Ismail
dc.contributor.authorAk, Tuba Parlak
dc.contributor.authorBasak, Nese
dc.contributor.authorGulluoglu, Hakan
dc.date.accessioned2024-08-04T20:09:57Z
dc.date.available2024-08-04T20:09:57Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThirty-six Sprague Dawley male rats were housed in individual cages and randomly divided into six groups: control, copper sulfate (Cu; 500 ppm body weight (BW)/day), flunixin meglumine (FM; 2.2 ppm BW/day), chrysin (chrysin; 50 ppm BW/day), copper sulfate + FM (Cu + FM; 500 ppm BW/day of copper sulfate and 2.2 ppm BW/day of FM), and copper sulfate + chrysin (Cu + Chrysin; 500 ppm BW/day of copper sulfate and 50 ppm BW/day of chrysin). Feed intake (FI) in the Cu + Chrysin group significantly increased in comparison with that of the Cu group (P < 0.01). Cu excess significantly increased malondialdehyde, indicating oxidative stress. Chrysin and FM administration significantly decreased malondialdehyde levels and increased the superoxide dismutase and catalase activities in the liver and kidney tissues (P < 0.001). Serum TNF-a levels were significantly lower in the Cu + FM and Cu + Chrysin groups in comparison to the Cu group (P < 0.001). It was seen that FM and chrysin treatments alleviated degeneration, necrosis, and apoptosis in the liver and kidney tissues of the Cu-treated rats. Chrysin appeared to ameliorate the adverse effects on FI and liver and kidney tissues by scavenging where the free radicals are located and increasing the activity of antioxidants.en_US
dc.description.sponsorshipFirat University Scientific Research Projects Unit [VF.14.11]en_US
dc.description.sponsorshipThe present research was funded by Firat University Scientific Research Projects Unit (VF.14.11).en_US
dc.identifier.doi10.3906/vet-1710-70
dc.identifier.endpage387en_US
dc.identifier.issn1300-0128
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-85055868517en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage376en_US
dc.identifier.trdizinid356712en_US
dc.identifier.urihttps://doi.org/10.3906/vet-1710-70
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/356712
dc.identifier.urihttps://hdl.handle.net/11616/92513
dc.identifier.volume42en_US
dc.identifier.wosWOS:000447163600002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technological Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal of Veterinary & Animal Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntioxidant statusen_US
dc.subjectbody weight changeen_US
dc.subjectchrysinen_US
dc.subjectcopperen_US
dc.subjectflunixin meglumineen_US
dc.subjecthistological changesen_US
dc.titleThe protective effects of chrysin and flunixin meglumine against excess copper in male ratsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu