The Beneficial Effects of Vitamin D3 Against Trichloroethylene Toxicity in Rat Ovaries

Basit Öğe Kaydı
dc.contributor.authorBağcı, Helin
dc.contributor.authorMelekoğlu, Rauf
dc.contributor.authorÇelik Kavak, Ebru
dc.contributor.authorKuloğlu, Tuncay
dc.contributor.authorŞimşek, Memet
dc.date.accessioned2021-03-22T13:56:21Z
dc.date.available2021-03-22T13:56:21Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAbstract: Objective: Vitamin D3 is an active metabolite of vitamin D and has been reported to have anti-oxidative effects due to inhibition of lipid peroxidation in some tissues both in vitro and in vivo studies. The current study was carried out to assess the protective effects of vitamin D3 on experimental trichloroethylene (TCE) toxicity in rat ovaries by using immunohistochemical detection of malondialdehyde (MDA) in tissues as well as histopathological scores’ computation. Material and Methods: Twenty-four healthy rats were randomly divided into four equivalent groups: control (sham-operated), TCE+vitamin D3 (1000 mg/kg/day and 50 IU/day, in that order), TCE (1000 mg/kg/day), as well as vitamin D3 (50 IU/day). Histopathological and immunohistochemical analyses were carried out on tissue samples 21 days following exposure to vitamin D3 and TCE. Results: Histopathological examination showed a significant decrease of angiogenesis in the corpus luteum and a substantial degeneration in the ovarian follicles and germinal epithelium in ovarian tissues of TCE group. Also, immunohistochemical examination for MDA immunoreactivity revealed that MDA immunoreactivity was significantly increased in the TCE group compared to the control group. We observed that vitamin D3 administration improved histological parameters, which include follicular degeneration as well as germinal epithelium degeneration, limiting TCE’s negative impacts on ovarian tissues. It was also confirmed that MDA immunoreactivity was considerably reduced in ovarian tissues in the TCE + vitamin D3 group. Conclusion: In this study, the significant improvements observed in immunohistochemical and histopathological tissue oxidative stress parameters indicate that treatment with vitamin D3 could be a conservative method to prevent ovarian TCE toxicity.en_US
dc.identifier.citationBAĞCI H,MELEKOĞLU R,KAVAK E. Ç,KULOĞLU T,ŞİMŞEK M (2020). The Beneficial Effects of Vitamin D3 Against Trichloroethylene Toxicity in Rat Ovaries. Journal of Clinical Obstetrics & Gynecology, 30(2), 65 - 72. Doi: 10.5336/jcog.2020-75002en_US
dc.identifier.doi10.5336/jcog.2020-75002en_US
dc.identifier.endpage72en_US
dc.identifier.issn2619-9467
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85095697467en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage65en_US
dc.identifier.trdizinid380294en_US
dc.identifier.urihttps://doi.org/10.5336/jcog.2020-75002
dc.identifier.urihttps://hdl.handle.net/11616/19666
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/380294
dc.identifier.volume30en_US
dc.identifier.wosWOS:000871239900004en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.relation.ispartofJournal of Clinical Obstetrics & Gynecologyen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleThe Beneficial Effects of Vitamin D3 Against Trichloroethylene Toxicity in Rat Ovariesen_US
dc.typeArticleen_US

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