SYNTHESIS, CHARACTERIZATION, AND BIOLOGICAL ACTIVITY OF 1,3-DISUBSTITUTED BENZIMIDAZOLIUM SALT AND ITS Ag-NHC COMPLEX
Küçük Resim Yok
Tarih
2023
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Soc Chemists Technologists Madeconia
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
In this study, a 1,3-dioxane functionalized benzimidazole salt and its Ag-complex were synthe-sized. The prepared compounds were structurally verified by several spectroscopic techniques including 1H NMR, 13C NMR, FT-IR, LC-MS, and C, H, N analysis. Compounds were evaluated for their in vitro antioxidant activity. The salts and their Ag-NHC complexes were further evaluated for their in vitro anti-cancer activities against HCT-116 human colon cancer cells. The results showed that complex 2 exhibited high activity (4.1 times) against the cancer cell lines studied when compared to the reference drug cispla-tin. Stability studies demonstrated that these compounds are stable in aqueous and organic solutions.
Açıklama
Anahtar Kelimeler
silver complexes, N-heterocyclic carbene, benzimidazole, 1, 3-dioxane, antioxidant and anticancer activity
Kaynak
Macedonian Journal of Chemistry and Chemical Engineering
WoS Q Değeri
Q3
Scopus Q Değeri
Q4
Cilt
42
Sayı
1
