SYNTHESIS, CHARACTERIZATION, AND BIOLOGICAL ACTIVITY OF 1,3-DISUBSTITUTED BENZIMIDAZOLIUM SALT AND ITS Ag-NHC COMPLEX

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dc.contributor.authorUlu, Oznur Dogan
dc.date.accessioned2024-08-04T20:53:42Z
dc.date.available2024-08-04T20:53:42Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn this study, a 1,3-dioxane functionalized benzimidazole salt and its Ag-complex were synthe-sized. The prepared compounds were structurally verified by several spectroscopic techniques including 1H NMR, 13C NMR, FT-IR, LC-MS, and C, H, N analysis. Compounds were evaluated for their in vitro antioxidant activity. The salts and their Ag-NHC complexes were further evaluated for their in vitro anti-cancer activities against HCT-116 human colon cancer cells. The results showed that complex 2 exhibited high activity (4.1 times) against the cancer cell lines studied when compared to the reference drug cispla-tin. Stability studies demonstrated that these compounds are stable in aqueous and organic solutions.en_US
dc.identifier.doi10.20450/mjcce.2023.2589
dc.identifier.issn1857-5552
dc.identifier.issn1857-5625
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85159141164en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.urihttps://doi.org/10.20450/mjcce.2023.2589
dc.identifier.urihttps://hdl.handle.net/11616/101348
dc.identifier.volume42en_US
dc.identifier.wosWOS:000985390100001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSoc Chemists Technologists Madeconiaen_US
dc.relation.ispartofMacedonian Journal of Chemistry and Chemical Engineeringen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectsilver complexesen_US
dc.subjectN-heterocyclic carbeneen_US
dc.subjectbenzimidazoleen_US
dc.subject1en_US
dc.subject3-dioxaneen_US
dc.subjectantioxidant and anticancer activityen_US
dc.titleSYNTHESIS, CHARACTERIZATION, AND BIOLOGICAL ACTIVITY OF 1,3-DISUBSTITUTED BENZIMIDAZOLIUM SALT AND ITS Ag-NHC COMPLEXen_US
dc.typeArticleen_US

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