Immobilization of L-Asparaginase on Carrier Materials: A Comprehensive Review
Küçük Resim Yok
Tarih
2017
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Amer Chemical Soc
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
There are two major applications of L-asparaginase (L-ASNase): leukemia therapy and the food industry. Especially, its chemotherapeutic effect has attracted interest from the scientific community and individual scientists. Therefore, to protect the intrinsic activity and half-time of L-ASNase, several carriers and immobilization techniques for immobilization of L-ASNase have been described in articles. Unfortunately, a comprehensive review about immobilization of L-ASNase has not been written until now. In this review, we have thoroughly discussed the carriers for L-ASNase by illustrating immobilization findings including both past and present applications. In addition, we have revealed advantages and disadvantages of immobilized enzyme and related it to free form. We believe that this review will not only provide background information, but also guide future developments.
Açıklama
Anahtar Kelimeler
Langmuir-Blodgett-Films, Conjugated L-Asparaginase, Enzyme L-Asparaginase, Coli L-Asparaginase, Polyethylene-Glycol, Peg-Asparaginase, Nanoparticles, Stabilization, Chitosan, Therapy
Kaynak
Bioconjugate Chemistry
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
Cilt
28
Sayı
6
