The role of Crocin in an acrylamide-induced neurotoxicity model in Wistar rats
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Tarih
2019
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Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Abstract: Aim: The changes in rat brain tissues treated with Crocin (Cr) as a protective agent in an acrylamide (AA) neurotoxicity model wereinvestigated.Material and Methods: The present with of the experimental animal ethics committee at Inonu University, Faculty of Medicine (2016/ A-59). Forty male rats were randomly divided into 4 groups with study was conducted the approval equal number of rats (10): Control, Cr, AA, Cr + AA Groups. Malondialdehyde (MDA), reduced glutathione (GSH), total antioxidant status (TAS), total oxidantstatus (TOS), Oxidative stress index (OSI), superoxide dismutase (SOD), catalase (CAT) and protein values were examined in thebrain tissues.Results: MDA, TOS and OSI levels increased in brain tissues of AA administered rats when compared to the other groups, whilethe GSH, TAS, SOD and CAT levels decreased in the group (p < 0.05). GSH, TAS, SOD and CAT levels increased, but MDA, TOS andOSI levels decreased in the AA + Cr administered group when compared to the AA group (p < 0.05). It was observed that oral AAadministration altered the antioxidant/oxidant balance favoring the oxidants in male rat brain tissues, leading to oxidative stressinduced neurotoxicity, while Cr administration reestablished the normal antioxidant/oxidant balance, preventing the oxidative stressinduced neurotoxicity via detoxification.Conclusion: The present study concluded that the administered Cr dose was sufficient to prevent neurotoxicity and we recommendthat adequate amounts of Cr should be consumed to prevent AA-induced toxicity and improve antioxidant capacity.
Açıklama
Anahtar Kelimeler
Kaynak
Annals of Medical Research
WoS Q Değeri
Scopus Q Değeri
Cilt
26
Sayı
11
Künye
ERDEMLİ M. E,ERDEMLİ Z,BAĞ H. G,ALTINÖZ E (2019). The role of Crocin in an acrylamide-induced neurotoxicity
model in Wistar rats. Annals of Medical Research, 26(11), 2540 - 2544. Doi: 10.5455/annalsmedres.2019.09.551
