The role of Crocin in an acrylamide-induced neurotoxicity model in Wistar rats
| dc.contributor.author | Erdemli, Erman Mehmet | |
| dc.contributor.author | Erdemli, Zeynep | |
| dc.contributor.author | Gözükara Bağ, Harika | |
| dc.contributor.author | Altinoz, Eyüp | |
| dc.date.accessioned | 2021-12-27T14:07:45Z | |
| dc.date.available | 2021-12-27T14:07:45Z | |
| dc.date.issued | 2019 | |
| dc.department | İnönü Üniversitesi | en_US |
| dc.description.abstract | Abstract: Aim: The changes in rat brain tissues treated with Crocin (Cr) as a protective agent in an acrylamide (AA) neurotoxicity model wereinvestigated.Material and Methods: The present with of the experimental animal ethics committee at Inonu University, Faculty of Medicine (2016/ A-59). Forty male rats were randomly divided into 4 groups with study was conducted the approval equal number of rats (10): Control, Cr, AA, Cr + AA Groups. Malondialdehyde (MDA), reduced glutathione (GSH), total antioxidant status (TAS), total oxidantstatus (TOS), Oxidative stress index (OSI), superoxide dismutase (SOD), catalase (CAT) and protein values were examined in thebrain tissues.Results: MDA, TOS and OSI levels increased in brain tissues of AA administered rats when compared to the other groups, whilethe GSH, TAS, SOD and CAT levels decreased in the group (p < 0.05). GSH, TAS, SOD and CAT levels increased, but MDA, TOS andOSI levels decreased in the AA + Cr administered group when compared to the AA group (p < 0.05). It was observed that oral AAadministration altered the antioxidant/oxidant balance favoring the oxidants in male rat brain tissues, leading to oxidative stressinduced neurotoxicity, while Cr administration reestablished the normal antioxidant/oxidant balance, preventing the oxidative stressinduced neurotoxicity via detoxification.Conclusion: The present study concluded that the administered Cr dose was sufficient to prevent neurotoxicity and we recommendthat adequate amounts of Cr should be consumed to prevent AA-induced toxicity and improve antioxidant capacity. | en_US |
| dc.identifier.citation | ERDEMLİ M. E,ERDEMLİ Z,BAĞ H. G,ALTINÖZ E (2019). The role of Crocin in an acrylamide-induced neurotoxicity model in Wistar rats. Annals of Medical Research, 26(11), 2540 - 2544. Doi: 10.5455/annalsmedres.2019.09.551 | en_US |
| dc.identifier.doi | 10.5455/annalsmedres.2019.09.551 | en_US |
| dc.identifier.endpage | 2544 | en_US |
| dc.identifier.issn | 2636-7688 | |
| dc.identifier.issue | 11 | en_US |
| dc.identifier.startpage | 2540 | en_US |
| dc.identifier.trdizinid | 358464 | en_US |
| dc.identifier.uri | https://doi.org/10.5455/annalsmedres.2019.09.551 | |
| dc.identifier.uri | https://hdl.handle.net/11616/44554 | |
| dc.identifier.uri | https://search.trdizin.gov.tr/yayin/detay/358464 | |
| dc.identifier.volume | 26 | en_US |
| dc.indekslendigikaynak | TR-Dizin | en_US |
| dc.language.iso | en | en_US |
| dc.relation.ispartof | Annals of Medical Research | en_US |
| dc.relation.publicationcategory | Makale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| dc.rights | info:eu-repo/semantics/openAccess | en_US |
| dc.title | The role of Crocin in an acrylamide-induced neurotoxicity model in Wistar rats | en_US |
| dc.type | Article | en_US |
