Histopathologic and Electron Microscopic Investigation of the Effects of Parenteral Nutrition Combined with Starvation on Kidney Tissue of Rabbits

dc.authoridGozukara Bag, Harika Gozde/0000-0003-1208-4072
dc.authoridGURUNLUOGLU, SEMRA/0000-0002-9737-859X
dc.authorwosidGozukara Bag, Harika Gozde/ABG-7588-2020
dc.contributor.authorGurunluoglu, Semra
dc.contributor.authorGul, Mehmet
dc.contributor.authorGozukara, Harika
dc.date.accessioned2024-08-04T20:10:10Z
dc.date.available2024-08-04T20:10:10Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: To conduct a histopathologic examination of the effects of a combination of parenteral nutrition (PN) and starvation on rabbits' kidney tissue using light microscopy and transmission electron microscopy. Methods: Four groups consisting of equal numbers of adult female and male New Zealand rabbits were formed (n = 14 each). Rabbits in the PN + oral feeding group were provided with half of their daily caloric needs from rabbit feed and the other half through PN. Rabbits in the PN + starvation group received a full dose of PN daily and received no feed. Rabbits in the half-starvation group were provided with rabbit feed covering only half their daily caloric needs. Rabbits in the control group were provided with all their caloric needs from rabbit feed. After 10 days, all the rabbits were weighed, anesthetized, and euthanized, and their kidney tissue samples were collected. Histopathologic examination was performed by a surgical pathologist blinded to the experimental groups. Results: The kidney tissue samples of rabbits in the PN + starvation group showed mild tubular dilatation, mild tubular degeneration, moderate renal inflammation, mild interstitial fibrosis, and increased apoptosis. The destructive effects were considerably milder in the PN + oral feeding group. Conclusion: PN combined with starvation can cause devastating damage to the kidneys. The damage can be minimized by combining PN with enteral nutrition.en_US
dc.identifier.doi10.5152/turkjnephrol.2021.21637
dc.identifier.endpage278en_US
dc.identifier.issn2667-4440
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85128608527en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage269en_US
dc.identifier.trdizinid478989en_US
dc.identifier.urihttps://doi.org/10.5152/turkjnephrol.2021.21637
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/478989
dc.identifier.urihttps://hdl.handle.net/11616/92639
dc.identifier.volume30en_US
dc.identifier.wosWOS:000710457200004en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherAvesen_US
dc.relation.ispartofTurkish Journal of Nephrologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectKidneyen_US
dc.subjectparenteral nutritionen_US
dc.subjectstarvationen_US
dc.subjectpathologyen_US
dc.subjectimpairmenten_US
dc.titleHistopathologic and Electron Microscopic Investigation of the Effects of Parenteral Nutrition Combined with Starvation on Kidney Tissue of Rabbitsen_US
dc.typeArticleen_US

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