Microvascular Invasion in Hepatocellular Carcinoma: Some Puzzling Facets

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dc.authoridGARZALI, IBRAHIM UMAR/0000-0002-9797-851X
dc.authorwosidGARZALI, IBRAHIM UMAR/ITU-1475-2023
dc.contributor.authorGarzali, Ibrahim Umar
dc.contributor.authorCarr, Brian I.
dc.contributor.authorInce, Volkan
dc.contributor.authorIsik, Burak
dc.contributor.authorAkatli, Ayse Nur
dc.contributor.authorYilmaz, Sezai
dc.date.accessioned2024-08-04T20:10:24Z
dc.date.available2024-08-04T20:10:24Z
dc.date.issued2024
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground/Aims: Hepatocellular carcinoma is the main type of primary liver cancer. Macroscopic vascular invasion is usually identified during imaging, whereas microvascular invasion is usually determined by histopathological evaluation. We aim to identify the association between microvascular invasion and other markers of tumor aggressiveness and to identify the role of microvascular invasion in the prognosis of patients who were treated by liver transplantation for hepatocellular carcinoma. Materials and Methods: This is a single -center retrospective analysis of prospectively collected data. Patients who received liver transplantation for hepatocellular carcinoma were included in the study. Data were collected regarding sociodemographic variables, criteria of selection for liver transplantation, pretransplant alpha-fetoprotein, presence or absence of microvascular invasion, presence or absence of recurrence, overall survival, and disease -free survival. Data were analyzed using Statistical Package for the Social Sciences. Results: Sociodemographic laboratory values and radiologic tumor characteristics were found to be similar infconclu patients with or without microvascular invasion. Our study revealed that microvascular invasion is associated with increased recurrence, decreased diseasedfree survival, and decreased overall survival, only for patients with hepatocellular carcinoma beyond Milan criteria at the time of liver transplantation. Conclusion: For patients beyond Milan criteria, but not within Milan criteria, microvascular invasion plays a significant role in predicting recurrence and shorter survival after liver transplantation.en_US
dc.identifier.doi10.5152/tjg.2024.22769
dc.identifier.issn2148-5607
dc.identifier.issue2en_US
dc.identifier.pmid38454246en_US
dc.identifier.scopus2-s2.0-85185342207en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.trdizinid1239631en_US
dc.identifier.urihttps://doi.org/10.5152/tjg.2024.22769
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1239631
dc.identifier.urihttps://hdl.handle.net/11616/92764
dc.identifier.volume35en_US
dc.identifier.wosWOS:001186799900012en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAvesen_US
dc.relation.ispartofTurkish Journal of Gastroenterologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHepatocellular carcinomaen_US
dc.subjectmicrovascular invasionen_US
dc.subjectsurvivalen_US
dc.subjectsizeen_US
dc.titleMicrovascular Invasion in Hepatocellular Carcinoma: Some Puzzling Facetsen_US
dc.typeArticleen_US

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