Effects of ketamine propofol mixture on intraocular pressure and hemodynamic in elderly patients a randomized double blind trial

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dc.authorid9217en_US
dc.contributor.authorAydoğan, Mustafa Said
dc.contributor.authorDemirel, Soner
dc.contributor.authorErdoğan, Mehmet Ali
dc.contributor.authorFırat, Penpegül
dc.contributor.authorÇolak, Cemil
dc.contributor.authorDurmuş, Mahmut
dc.date.accessioned2017-08-18T07:47:06Z
dc.date.available2017-08-18T07:47:06Z
dc.date.issued2014
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: The aim of this study was to compare the effects of a ketamine-propofol mixture (ketofol) and propofol on intraocular pressure (IOP) and haemodynamics in elderly patients during anaesthetic management at each repeated measurement times. Methods: Forty elderly ASA I and II patients were divided into two random groups and received either propofol (1.5 mg kg-1; group P, n=20) or ketofol (1:1 single syringe mixture of 5 mg mL-1 ketamine and 5 mg mL-1 propofol; group KP, n=20). A proseal laryngeal mask airway (PLMA) was inserted 60 seconds after induction of anaesthesia. IOP, systolic blood pressure (SBP), diastolic blood pressure (DBP), and heart rate (HR) values were recorded at preinduction (t0), immediately following induction (t1), and at 1 (t2), 3 (t3), and 5 (t4) minutes after induction. Haemodynamic complications and the need for ephedrine were also recorded. Results: Patient characteristics at the beginning of the procedure were similar between the groups. SBP and HR were significantly increased in group KP compared to group P at t1 and t4 (p=0.044). Induction of both anaesthetic agents significantly decreased the IOP values from the t0 (p=0.026). A significant decrease in IOP was found at t1 and t4 in group P compared to group KP (p=0.018). The total dose of ephedrine was statistically different in group P (p=0.034). Conclusion: Ketofol can be an alternative agent to provide haemodynamic stability with a moderate decrease in IOP during anaesthesia induction in elderly patients.en_US
dc.identifier.citationAydoğan, M. S. Demirel, S. Erdoğan, M. A. Fırat, P. Çolak, C. Durmuş, M. (2014). Effects of ketamine propofol mixture on intraocular pressure and hemodynamic in elderly patients a randomized double blind trial. Turkish Journal of Anesthesia and Reanimation. 42. 12-18.en_US
dc.identifier.doi10.5152/TJAR.2013.56en_US
dc.identifier.endpage18en_US
dc.identifier.startpage12en_US
dc.identifier.urihttps://hdl.handle.net/11616/7621
dc.identifier.volume42en_US
dc.language.isoenen_US
dc.publisherTurkish Journal of Anesthesia and Reanimationen_US
dc.relation.ispartofTurkish Journal of Anesthesia and Reanimationen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIntraocular pressureen_US
dc.subjectHemodynamicen_US
dc.subjectKetamineen_US
dc.subjectPropofolen_US
dc.subjectElderly patienten_US
dc.titleEffects of ketamine propofol mixture on intraocular pressure and hemodynamic in elderly patients a randomized double blind trialen_US
dc.typeArticleen_US

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