The protective cardiac effects of myrcene after global cerebral ıschemia reperfusion in C57BL J6 mouse
Yükleniyor...
Dosyalar
Tarih
2016
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Acta cir bras
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
ABSTRACT
PURPOSE: To investigate the protective effect of β-myrcene (MYR) on oxidative and histological damage in mice heart tissue caused
global cerebral ischemia/reperfusion (IR) in C57BL/J6 mice.
METHODS: Animals(n=40) were randomly divided into four groups: (1)control, (2)IR, (3)MYR and (4)MYR+IR. The control group
was received 0.1% carboxymethyl cellulose as a vehicle following a medial incision without carotid occlusion. In the IR group, the
bilateral carotid arteries were clipped for 15min, and treated with the vehicle intraperitoneally(ip) for 10 days. MYR (200mg/kg) was
received dissolved in 0.1%CMC for 10 days. In the MYR+IR group, the IR model was applied exactly as in the IR group, and then they
were treated with MYR 10 days.
RESULTS: The cerebral IR caused oxidative damage (increase TBARS, decrease antioxidant parameters). Treatment of MYR was
increased in GSH,GPx,CAT,SOD activity while TBARS level was decreased. In addition, degenerative changes in I/R group heart tissue
were ameliorated by MYR administration.
CONCLUSİON: The administration of β-myrcene protects oxidative and histological damage in the heart tissue after global ischemiareperfusion
and may be useful safe alternative treatment for cardiac tissue after ischemic stroke.
Açıklama
Anahtar Kelimeler
Brain Ischemia, Reperfusion, Oxidative Stress, Mice
Kaynak
Acta cir bras
WoS Q Değeri
Scopus Q Değeri
Cilt
31
Sayı
7
Künye
Baykalır, B. G. Çiftçi, O. Çetin, A. Öztanır, M. N. Başak, N. (2016). The protective cardiac effects of myrcene after global cerebral ıschemia reperfusion in C57BL J6 mouse . Acta Cir Bras., 456-462.
