The protective cardiac effects of myrcene after global cerebral ıschemia reperfusion in C57BL J6 mouse

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dc.authoridTR58659en_US
dc.authoridTR102040en_US
dc.authoridTR52354en_US
dc.authoridTR107942en_US
dc.authoridTR103979en_US
dc.contributor.authorBaykalır, Burcu Gül
dc.contributor.authorÇiftçi, Osman
dc.contributor.authorÇetin, Aslı
dc.contributor.authorÖztanır, Mustafa Namık
dc.contributor.authorBaşak, Neşe
dc.date.accessioned2017-04-14T10:30:43Z
dc.date.available2017-04-14T10:30:43Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractABSTRACT PURPOSE: To investigate the protective effect of β-myrcene (MYR) on oxidative and histological damage in mice heart tissue caused global cerebral ischemia/reperfusion (IR) in C57BL/J6 mice. METHODS: Animals(n=40) were randomly divided into four groups: (1)control, (2)IR, (3)MYR and (4)MYR+IR. The control group was received 0.1% carboxymethyl cellulose as a vehicle following a medial incision without carotid occlusion. In the IR group, the bilateral carotid arteries were clipped for 15min, and treated with the vehicle intraperitoneally(ip) for 10 days. MYR (200mg/kg) was received dissolved in 0.1%CMC for 10 days. In the MYR+IR group, the IR model was applied exactly as in the IR group, and then they were treated with MYR 10 days. RESULTS: The cerebral IR caused oxidative damage (increase TBARS, decrease antioxidant parameters). Treatment of MYR was increased in GSH,GPx,CAT,SOD activity while TBARS level was decreased. In addition, degenerative changes in I/R group heart tissue were ameliorated by MYR administration. CONCLUSİON: The administration of β-myrcene protects oxidative and histological damage in the heart tissue after global ischemiareperfusion and may be useful safe alternative treatment for cardiac tissue after ischemic stroke.en_US
dc.identifier.citationBaykalır, B. G. Çiftçi, O. Çetin, A. Öztanır, M. N. Başak, N. (2016). The protective cardiac effects of myrcene after global cerebral ıschemia reperfusion in C57BL J6 mouse . Acta Cir Bras., 456-462.en_US
dc.identifier.doi10.1590/S0102-865020160070000005en_US
dc.identifier.endpage462en_US
dc.identifier.issue7en_US
dc.identifier.startpage456en_US
dc.identifier.urihttp://dx.doi.org/10.1590/S0102-865020160070000005
dc.identifier.urihttps://hdl.handle.net/11616/6668
dc.identifier.volume31en_US
dc.language.isoenen_US
dc.publisherActa cir brasen_US
dc.relation.ispartofActa cir brasen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBrain Ischemiaen_US
dc.subjectReperfusionen_US
dc.subjectOxidative Stressen_US
dc.subjectMiceen_US
dc.titleThe protective cardiac effects of myrcene after global cerebral ıschemia reperfusion in C57BL J6 mouseen_US
dc.typeArticleen_US

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