Effects of Hexachlorocyclohexane (HCH-?-Isomer, Lindane) on the Reproductive System of Zebrafish (Danio rerio)

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dc.authoridUlucan, Aykut/0000-0001-8844-8237
dc.authoridUlucan, Aykut/0000-0001-8844-8237;
dc.authorwosidUlucan, Aykut/N-9142-2019
dc.authorwosidUlucan, Aykut/P-3035-2016
dc.authorwosidIspir, Unal/JSK-1533-2023
dc.contributor.authorYuksel, Hayati
dc.contributor.authorIspir, Unal
dc.contributor.authorUlucan, Aykut
dc.contributor.authorTurk, Cebrahil
dc.contributor.authorTaysi, M. Resit
dc.date.accessioned2024-08-04T20:42:46Z
dc.date.available2024-08-04T20:42:46Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn this study, histopathological changes induced by lindane a gamma isomer of hexachlorocyclohexane and its intoxication associated with reproductive system and hormone levels were investigated in zebrafish. In all, 320 zebrafish adults approximately 1 year in age, (Danio rerio) obtained from a commercial entity were used in the study. Zebrafish were divided into 8 groups, each one containing 40 zebrafish. Groups were organized as 0 (the control group), 1 ml/L methanol, and 5, 10, 20, 40, 80, 160 mu g/L/day lindane. In the study, the gamma-HCH-isomer was applied at rates of 5/10/20/40/80/160 mu g/L/day as doses of immersion to each group for 21 days. Macroscopically, the drop in egg production was observed, especially in the 80 and 160 mu g/L/day groups of female zebrafish. A microscopic decrease in ovulation and biochemical decreases in estradiol (E-2) levels (40/80/160 mu g/L) were also observed in the female zebrafish. As a result, lindane was found to cause changes in the reproductive system, and consequently, to cause hormonal disorders and to have significant effects on ovulation and fertilization in the female zebrafish.en_US
dc.description.sponsorshipBingol University, Turkey, Scientific Research Project Council [21/2010]en_US
dc.description.sponsorshipThis Study was supported by Bingol University, Turkey, Scientific Research Project Council, Project Number 21/2010.en_US
dc.identifier.doi10.4194/1303-2712-v16_4_19
dc.identifier.endpage921en_US
dc.identifier.issn1303-2712
dc.identifier.issn2149-181X
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-84995642073en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage917en_US
dc.identifier.urihttps://doi.org/10.4194/1303-2712-v16_4_19
dc.identifier.urihttps://hdl.handle.net/11616/97585
dc.identifier.volume16en_US
dc.identifier.wosWOS:000388312400019en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherCentral Fisheries Research Insten_US
dc.relation.ispartofTurkish Journal of Fisheries and Aquatic Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectZebrafishen_US
dc.subjectovulationen_US
dc.subjectfertilizationen_US
dc.subjecthistopathologyen_US
dc.titleEffects of Hexachlorocyclohexane (HCH-?-Isomer, Lindane) on the Reproductive System of Zebrafish (Danio rerio)en_US
dc.typeArticleen_US

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