Formulation and In Vitro Evaluation of Telmisartan Nanoparticles Prepared by Emulsion-Solvent Evaporation Technique

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dc.authoridOzturk, Naile/0000-0002-7617-8433;
dc.authorwosidOzturk, Naile/F-3650-2017
dc.authorwosidKara, Asli/ABB-8903-2021
dc.contributor.authorOzturk, Naile
dc.contributor.authorKara, Asli
dc.contributor.authorVural, Imran
dc.date.accessioned2024-08-04T20:10:02Z
dc.date.available2024-08-04T20:10:02Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjectives: Telmisartan (TLM) is an antihypertensive drug that has been shown to have antiproliferative effects on cancer cells. It has low solubility and suboptimal oral bioavailability. To investigate the potential anticancer effect of TLM on breast cancer cells, poly (D, L-lactide) (PLA) nanoparticles were formulated with the benefit of improving its solubility. Materials and Methods: TLM-loaded PLA nanoparticles were prepared by emulsion solvent evaporation. The effects of sonication time and polymer:drug ratio on nanoparticle size and drug encapsulation were investigated. TLM-loaded nanoparticles were tested against MCF-7 and MDA-MB-231 breast cancer cell lines for antiproliferative effects. Results: Nanoparticles with mean particle size 272 nm and 79% encapsulation efficiency were obtained. Sustained release TLM nanoparticles (40% in 24 h) decreased cell viability to 45% for MCF-7 cells at 72 h, even at the lowest TLM concentration, indicating better anticancer efficiency than TLM solution. Conclusion: TLM nanoparticles could be potential anticancer agents for breast cancer and deserve further studies.en_US
dc.identifier.doi10.4274/tjps.galenos.2019.76402
dc.identifier.endpage499en_US
dc.identifier.issn1304-530X
dc.identifier.issue5en_US
dc.identifier.pmid33177929en_US
dc.identifier.scopus2-s2.0-85094607914en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage492en_US
dc.identifier.trdizinid410561en_US
dc.identifier.urihttps://doi.org/10.4274/tjps.galenos.2019.76402
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/410561
dc.identifier.urihttps://hdl.handle.net/11616/92568
dc.identifier.volume17en_US
dc.identifier.wosWOS:000585327200006en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkish Pharmacists Assocen_US
dc.relation.ispartofTurkish Journal of Pharmaceutical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectTelmisartanen_US
dc.subjectnanoparticlesen_US
dc.subjectanticancer effecten_US
dc.subjectdrug repositioningen_US
dc.titleFormulation and In Vitro Evaluation of Telmisartan Nanoparticles Prepared by Emulsion-Solvent Evaporation Techniqueen_US
dc.typeArticleen_US

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