Histological changes in the rat thoracic aorta after chronic nitric oxide synthase inhibition
Yükleniyor...
Dosyalar
Tarih
2003
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Turkish Journal of Medical Sciences
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Abstract: The objective of this study was to determine the morphological effects of chronic nitric oxide (NO) inhibition oh the thoracic aorta of Wistar rats. Fifteen male Wistar albino rats were divided into three groups. Group 1 rats (control group, n=5) received tap water, group II rats (n=5) recieved 100 mg/lg L-NAME (madatate NO inhibition) and group III rats (n= 5) received 500 mg/lg L-NAME, in drinking water (severe NO inhibition) for 15 days. At the end of 15 days, the carotid arteries of the rats were cannulated and their blood pressure was measured. The rats were sacrificed and thoracic aorta segments were fixed 10% neutral buffered formalin solution and examined by light microscope. The blood pressure results were expressed as the arithmetic mean ± SEM. Statistical analysis of the data was performed by the Kruskal Wallis H test ( p < 0.05). The differences between the groups were evaluated by the Mann-Whitney U test. Group I showed normal blood pressure and histology. Groups II and III had hypertensive blood pressure and showed vascular wall thickening. Irregular luminal layers of the endothelial cell linings and increased intensity of anti-alpha-SMA labeling were seen in both experimental groups. Our results revealed that chronic NO inhibition led to hypertension and structural changes in the thoracic aorta wall in Wistar rats.
Açıklama
Yıl: 2003Cilt: 33Sayı: 3ISSN: 1300-0144 / 1303-6165Sayfa Aralığı: 141 - 147Metin Dili:İngilizce
Anahtar Kelimeler
Kaynak
Turkish Journal of Medical Sciences
WoS Q Değeri
Scopus Q Değeri
Q3
Cilt
33
Sayı
3
Künye
VARDI N,ÖZTÜRK F,FADILLIOĞLU E,OTLU A,YAĞMURCA M (2003). Histological changes in the rat thoracic aorta after chronic nitric oxide synthase inhibition. Turkish Journal of Medical Sciences, 33(3), 141 - 147.
