The effects of nitric oxide on rat stomach injury induced by acetylsalicylic acid

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dc.authorscopusid6602371887
dc.authorscopusid56244596600
dc.authorscopusid6701336286
dc.authorscopusid7006831777
dc.authorscopusid7004301483
dc.contributor.authorYa?murca M.
dc.contributor.authorUçar M.
dc.contributor.authorFadillio?lu E.
dc.contributor.authorErdo?an H.
dc.contributor.authorÖztürk F.
dc.date.accessioned2024-08-04T20:00:53Z
dc.date.available2024-08-04T20:00:53Z
dc.date.issued2009
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAim: Acetylsalicylic acid (ASA, aspirin), which is one of the most frequently used drugs in the world, causes severe gastric mucosal injury. Nitric oxide (NO) is synthesized from L-arginine by nitric oxide synthase (NOS). NOS can be inhibited by N?-nitro-L-arginine methyl ester (L-NAME) and stimulated by supplementing the diet with L-arginine (L-Arg). The aim of this study was to investigate the role of NO on gastric mucosal injury induced by ASA. Materials and Methods: Male Sprague-Dawley rats were divided into seven groups: control, ASA, ASA+L-NAME, ASA+L-Arg, ASA+L-Arg+L-NAME, only L-NAME, and only L-Arg groups. After administration of the drugs, the rats were decapitated and their stomachs were removed and fixed in 10% neutral-buffered formalin solution. Results: Mucosal erosion, intramucosal hemorrhage, inflammatory cell infiltration, gland cell detachment, and necrosis were observed in the ASA group. It was demonstrated that L-Arg administration decreased the gastric mucosal injury, whereas L-NAME administration increased the extent and severity of the gastric injury induced by ASA. L-Arg or L-NAME administration alone did not affect gastric mucosa. Conclusions: We concluded that NO may have protective effects on gastric mucosal injury induced by ASA. © TÜBITAK.en_US
dc.identifier.endpage19en_US
dc.identifier.issn1300-0144
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-63449085592en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage13en_US
dc.identifier.trdizinid87922en_US
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/87922
dc.identifier.urihttps://hdl.handle.net/11616/91077
dc.identifier.volume39en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Medical Sciencesen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcetylsalicylic aciden_US
dc.subjectMicroscopyen_US
dc.subjectNitric oxideen_US
dc.subjectStomach injuryen_US
dc.titleThe effects of nitric oxide on rat stomach injury induced by acetylsalicylic aciden_US
dc.typeConference Objecten_US

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