Synthesis, antibacterial and antifungal activities of electron-rich olefins derived benzimidazole compounds
Küçük Resim Yok
Tarih
2003
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier Masson SAS
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
New benzimidazole derivatives were synthesised by electron-rich olefines (7, 8 and 9) with appropriate reagents. The compounds synthesised were identified by 1H NMR, 13C NMR, FT-IR spectroscopic techniques and elemental analysis. All compounds studied in this work were screened for their in vitro antimicrobial activities against the standard strains: Enterococcus faecalis (ATCC 29212), Staphylococcus aureus (ATCC 29213), Escherichia coli (ATCC 25922), Pseudomonas aeruginosa (ATCC 27853) and the yeasts Candida albicans and Candida tropicalis. Eleven of the compounds inhibited the growth of gram-positive bacteria (E. faecalis and S. aureus) at MIC values between 50 and 400 ?g/ml. None of the compounds exhibit antimicrobial activity against Gram-negative bacteria (E. coli and P. Aeruginosa) at the concentrations studied (6.25-800 ?g/ml). Nine of the tested compounds showed an antifungal activity with a range of the MICs between 50 and 400 ?g/ml. © 2003 Éditions scientifiques et médicales Elsevier SAS. All rights reserved.
Açıklama
Anahtar Kelimeler
Antibacterial activities, Antifungal activities, Benzimidazole derivatives, Electron-rich olefins, In vitro studies
Kaynak
Farmaco
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
58
Sayı
6
